Twenty Years of Schizophrenia Research in the Northern Finland Birth Cohort 1966: A Systematic Review.

IF 3.6 Q1 PSYCHIATRY Schizophrenia Research and Treatment Pub Date : 2015-01-01 Epub Date: 2015-05-18 DOI:10.1155/2015/524875
Erika Jääskeläinen, Marianne Haapea, Nina Rautio, Pauliina Juola, Matti Penttilä, Tanja Nordström, Ina Rissanen, Anja Husa, Emmi Keskinen, Riikka Marttila, Svetlana Filatova, Tiina-Mari Paaso, Jenni Koivukangas, Kristiina Moilanen, Matti Isohanni, Jouko Miettunen
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引用次数: 41

Abstract

Birth cohort designs are useful in studying adult disease trajectories and outcomes, such as schizophrenia. We review the schizophrenia research performed in the Northern Finland Birth Cohort 1966 (NFBC 1966), which includes 10,934 individuals living in Finland at 16 years of age who have been monitored since each mother's mid-pregnancy. By the age of 44, 150 (1.4%) had developed schizophrenia. There are 77 original papers on schizophrenia published from the NFBC 1966. The early studies have found various risk factors for schizophrenia, especially related to pregnancy and perinatal phase. Psychiatric and somatic outcomes were heterogeneous, but relatively poor. Mortality in schizophrenia is high, especially due to suicides. Several early predictors of outcomes have also been found. Individuals with schizophrenia have alterations in brain morphometry and neurocognition, and our latest studies have found that the use of high lifetime doses of antipsychotics associated with these changes. The schizophrenia research in the NFBC 1966 has been especially active for 20 years, the prospective study design and long follow-up enabling several clinically and epidemiologically important findings. When compared to other birth cohorts, the research in the NFBC 1966 has offered also unique findings on course and outcome of schizophrenia.

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1966年芬兰北部出生队列二十年精神分裂症研究:系统回顾。
出生队列设计在研究成人疾病轨迹和结果(如精神分裂症)方面很有用。我们回顾了1966年芬兰北部出生队列(NFBC 1966)中进行的精神分裂症研究,其中包括10,934名生活在芬兰的16岁个体,从每位母亲怀孕中期开始监测。到44岁时,150人(1.4%)患上了精神分裂症。1966年NFBC发表了77篇关于精神分裂症的原创论文。早期的研究发现了精神分裂症的各种危险因素,特别是与妊娠和围产期有关。精神病学和躯体预后差异较大,但相对较差。精神分裂症的死亡率很高,尤其是自杀。还发现了几个早期的预测结果的因素。精神分裂症患者在脑形态和神经认知方面有改变,我们最新的研究发现,终生使用高剂量的抗精神病药物与这些改变有关。NFBC 1966的精神分裂症研究已经活跃了20年,前瞻性研究设计和长期随访使一些临床和流行病学上的重要发现成为可能。与其他出生队列相比,NFBC 1966的研究在精神分裂症的病程和结局方面也提供了独特的发现。
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
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