Combination of PAPPA, fhCGβ, AFP, PlGF, sTNFR1, and Maternal Characteristics in Prediction of Early-onset Preeclampsia.

Clinical Medicine Insights-Reproductive Health Pub Date : 2015-06-11 eCollection Date: 2015-01-01 DOI:10.4137/CMRH.S21865

Anna Yliniemi, Kaarin Makikallio, Teemu Korpimaki, Heikki Kouru, Jaana Marttala, Markku Ryynanen

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引用次数: 29

Abstract

Objective: To evaluate the efficacy of first-trimester markers-pregnancy-associated plasma protein A (PAPPA), free human chorionic gonadotropin β (fhCGβ), alpha-fetoprotein (AFP), placental growth factor (PlGF), and soluble tumor necrosis factor receptor-1 (sTNFR1) together with maternal characteristics (MC) for prediction of early-onset preeclampsia (EOPE).

Methods: During 2005-2010, the abovementioned biomarkers were analyzed with logistic regression analysis in 64 EOPE and 752 control subjects to determine whether these biomarkers separately and in combination with MC would predict development of EOPE.

Results: PAPPA, fhCGβ, and PlGF levels were lower, whereas AFP and sTNFR1 levels were higher in mothers with EOPE compared to controls. The combination of all markers with MC (age, weight, and smoking status) detected 48% of the mothers with EOPE, with a 10% false-positive rate (FPR).

Conclusions: First-trimester maternal serum levels of PAPPA, fhCGβ, AFP, PlGF, and sTNFR1, together with MC, are predictive of development of subsequent EOPE. These markers, along with MC, form a suitable panel for predicting EOPE.

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联合PAPPA、fhCGβ、AFP、PlGF、sTNFR1和母体特征预测早发性子痫前期

目的:评价妊娠前期标志物妊娠相关血浆蛋白A (PAPPA)、游离人绒毛膜促性腺激素β (fhCGβ)、甲胎蛋白(AFP)、胎盘生长因子(PlGF)、可溶性肿瘤坏死因子受体-1 (sTNFR1)及母体特征(MC)对早发性子痫前期(EOPE)的预测作用。方法:2005-2010年，对64例EOPE患者和752例对照患者的上述生物标志物进行logistic回归分析，以确定这些生物标志物单独或与MC联合是否能预测EOPE的发展。结果:与对照组相比，EOPE母亲的PAPPA、fhCGβ和PlGF水平较低，而AFP和sTNFR1水平较高。结合MC的所有标记(年龄、体重和吸烟状况)检测出48%的EOPE母亲，假阳性率(FPR)为10%。结论:妊娠早期孕妇血清中PAPPA、fhCGβ、AFP、PlGF和sTNFR1水平以及MC可预测随后的EOPE的发展。这些标记与MC一起构成了预测EOPE的合适面板。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Medicine Insights-Reproductive Health OBSTETRICS & GYNECOLOGY-

自引率

0.00%

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审稿时长

8 weeks

期刊介绍： Clinical Medicine Insights: Reproductive Health is a peer reviewed; open access journal, which covers all aspects of Reproduction: Gynecology, Obstetrics, and Infertility, spanning both male and female issues, from the physical to the psychological and the social, including: sex, contraception, pregnancy, childbirth, and related topics such as social and emotional impacts. It welcomes original research and review articles from across the health sciences. Clinical subjects include fertility and sterility, infertility and assisted reproduction, IVF, fertility preservation despite gonadotoxic chemo- and/or radiotherapy, pregnancy problems, PPD, infections and disease, surgery, diagnosis, menopause, HRT, pelvic floor problems, reproductive cancers and environmental impacts on reproduction, although this list is by no means exhaustive Subjects covered include, but are not limited to: • fertility and sterility, • infertility and ART, • ART/IVF, • fertility preservation despite gonadotoxic chemo- and/or radiotherapy, • pregnancy problems, • Postpartum depression • Infections and disease, • Gyn/Ob surgery, • diagnosis, • Contraception • Premenstrual tension • Gynecologic Oncology • reproductive cancers • environmental impacts on reproduction, • Obstetrics/Gynaecology • Women''s Health • menopause, • HRT, • pelvic floor problems, • Paediatric and adolescent gynaecology • PID