EFFECTS OF DEXAMETHASONE AND PHENIRAMINE MALEATE ON HEMODYNAMIC AND RESPIRATORY PARAMETERS AFTER CEMENTATION IN CEMENTED PARTIAL HIP PROSTHESIS.

Middle East Journal of Anesthesiology Pub Date : 2015-02-01

Abdulkadir Yektaş, Funda Gümüş, Tolga Totoz, Nurten Gül, Kerem Erkalp, Ayşin Alagöl

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Abstract

Purpose: To prevent hemodynamic and respiratory changes that are likely to occur during cementation in partial hip prosthesis by prophylactic use of pheniramine maleate and dexamethasone.

Methods and materials: The study included 40 patients aged between 60 and 85 years with an American Society ofAnesthesiologists (ASA) grade of II-III who underwent partial hip prosthesis. Just after spinal anesthesia, 4 mL normal saline was pushed in patients in Group S, whereas 45.5 mg pheniramine maleate and 8 mg dexamethasone mixture was pushed intravenously in a total volume of 4 mL in patients in Group PD.

Results: Amounts of atropine and adrenaline administered after cementation were significantly higher in Group S than in Group PD (P < 0.05). There was a significant difference between SpO2 values before and after cementation in Group S; SpO2 value was lower after cementation (P < 0.05) except for 1. min after cementation. SpO2 value increased 1 min after cementation (P = 0.031) CONCLUSION: Prophylactic use of pheniramine maleate and dexamethasone in partial hip prosthesis led to an increase in SpO2 value and a decrease in the utilization of adrenaline and atropine after cementation.

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地塞米松和马来酸苯那敏对骨水泥部分人工髋关节骨水泥后血流动力学和呼吸参数的影响。

目的:通过预防性使用马来酸苯那敏和地塞米松，预防部分髋关节假体骨水泥过程中可能发生的血流动力学和呼吸变化。方法和材料:该研究包括40例年龄在60至85岁之间的患者，美国麻醉学会(ASA)分级为II-III级，接受了部分髋关节假体。S组患者在脊髓麻醉刚结束时静脉推注生理盐水4ml, PD组患者静脉推注苯那敏加地塞米松混合物45.5 mg，共4ml。结果:S组骨水泥术后阿托品、肾上腺素用量显著高于PD组(P < 0.05)。S组固接前后SpO2值差异有统计学意义;除1组外，其余3组固接后SpO2值均低于对照组(P < 0.05)。胶结后最小。结论:部分髋关节假体预防性应用马酸苯那敏和地塞米松可导致骨水泥术后SpO2升高，肾上腺素和阿托品的利用率降低。

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来源期刊

Middle East Journal of Anesthesiology Medicine-Anesthesiology and Pain Medicine

CiteScore

0.20

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0.00%

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期刊介绍： The journal is published three times a year (February, June, and October) and has an Editorial Executive Committee from the department and consultant editors from various Arab countries. A volume consists of six issues. Presently, it is in its 42nd year of publication and is currently in its 19th volume. It has a worldwide circulation and effective March 2008, the MEJA has become an electronic journal. The main objective of the journal is to act as a forum for publication, education, and exchange of opinions, and to promote research and publications of the Middle Eastern heritage of medicine and anesthesia.