A rare B-cell type chronic active Epstein-Barr virus infection patient mimicking lymphoma on 18F-FDG PET/CT and literature review.

IF 2 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING American journal of nuclear medicine and molecular imaging Pub Date : 2022-08-20 eCollection Date: 2022-01-01
Hao Jiao, Yongbai Zhang, Zhao Chen, Xueqi Chen, Yongkang Qiu, Wenpeng Huang, Lin Nong, Lei Kang
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Abstract

A 13-year-old girl suffered from worsen snoring and persistent bilateral nasal congestion for one year. Paranasal sinus computed tomography (CT) and magnetic resonance imaging (MRI) found nasopharyngeal passages and sinus were occupied with soft tissues and bilateral neck enlarged lymph nodes 6 months ago. Tumor markers were normal. The titers of anti-Epstein-Barr virus (EBV) IgM, anti-EBV IgG, early antigen (EA) IgG, and Epstein-Barr nuclear antigen (EBNA) IgG increased. 2-Deoxy-2-[fluorine-18]-fluoro-D-glucose (18F-FDG) positron emission tomography combined with CT (PET/CT) revealed thickened soft tissues in nasopharynx and oropharynx, enlarged multiple lymph nodes in the neck, bilateral armpits, abdominal cavity and retroperitoneum, and pelvic cavity, diffuse thickening of the gastric wall of the antrum with hypermetabolism. According to the age, situation, regions, and abnormal FDG uptake, an initial diagnosis of EBV-related lymphoma was made. However, the pathological results of the nasopharyngeal mass and the abdominal lymph node confirmed the final diagnosis of a B-cell type chronic active Epstein-Barr virus disease (CAEBV), a rare type of EBV associated lymphoproliferative disorder (LPD). After receiving adoptive immune cells therapy, the EBV load decreased. At present, the patient is being followed up.

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一例罕见的b细胞型慢性活动性eb病毒感染患者的18F-FDG PET/CT及文献复习
一名13岁女孩因打鼾加重及持续双侧鼻塞一年。6个月前鼻窦CT及MRI检查发现鼻咽通道及鼻窦软组织占位,双侧颈部淋巴结肿大。肿瘤标志物正常。抗eb病毒(EBV) IgM、抗EBV IgG、早期抗原(EA) IgG、eb核抗原(EBNA) IgG滴度升高。2-脱氧-2-[氟-18]-氟- d -葡萄糖(18F-FDG)正电子发射断层扫描联合CT (PET/CT)示鼻咽部、口咽部软组织增厚,颈部、双侧腋窝、腹腔及腹膜后、盆腔多发淋巴结肿大,胃窦壁弥漫性增厚伴高代谢。根据年龄、情况、地区及FDG摄取异常情况,初步诊断ebv相关淋巴瘤。然而,鼻咽肿块和腹部淋巴结的病理结果证实了b细胞型慢性活动性eb病毒病(CAEBV)的最终诊断,这是一种罕见的eb病毒相关淋巴细胞增生性疾病(LPD)。接受过继性免疫细胞治疗后,EBV载量下降。目前正在对患者进行随访。
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来源期刊
American journal of nuclear medicine and molecular imaging
American journal of nuclear medicine and molecular imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
自引率
4.00%
发文量
4
期刊介绍: The scope of AJNMMI encompasses all areas of molecular imaging, including but not limited to: positron emission tomography (PET), single-photon emission computed tomography (SPECT), molecular magnetic resonance imaging, magnetic resonance spectroscopy, optical bioluminescence, optical fluorescence, targeted ultrasound, photoacoustic imaging, etc. AJNMMI welcomes original and review articles on both clinical investigation and preclinical research. Occasionally, special topic issues, short communications, editorials, and invited perspectives will also be published. Manuscripts, including figures and tables, must be original and not under consideration by another journal.
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