Huge unrepaired myelocystocele, progressive sac enlargement in later stages of life: a case report.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2025-02-01 Epub Date: 2022-09-08 DOI:10.1080/02688697.2022.2118235

Hosein Safari, Armin Jahangiri Babadi, Pooyan Alizadeh, Reza Ajudani, Soroor Hamidi

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Abstract

Background: Spinal dysraphism is characterized by failure of fusion at dorsal midline structures through the embryonic developmental stages. A terminal myelocystocele consists of a skin-covered lumbosacral spina bifida and meningocele that directly continuous with the spinal subarachnoid space.

Observation: A 43-year-old woman who was diagnosed at birth with myelocystocele in the lower segments of the lumbar spine. She was not operated in the early stages of life. At the 43th years of her old, during 9-months, the sac began to progressively increase in size. In our initial examination before surgery, an extremely large skin-covered myelocystocele sac was observed in the thoracolumbar with a diameter of approximately 60 * 70 * 40 cm. patient operated and sac repaired. More than 20 liter of cerebrospinal fluid drainaged from cyst during surgery.

Lessons: The mechanism of cyst enlargement is not well understood. Progressive and severe increase in size of unrepaired myelocystocele sac is possible in old ages even without cerebral hydrocephalus.

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巨大骨髓囊肿未修复，后期囊肿逐渐增大：病例报告。

背景：脊柱发育不良的特点是在胚胎发育阶段背中线结构融合失败。终末脊髓囊肿由皮肤覆盖的腰骶部脊柱裂和脑膜囊组成，直接与脊髓蛛网膜下腔相通：一名 43 岁女性，出生时被诊断为腰椎下段骨髓囊肿。她在出生早期没有接受过手术。43 岁时，在 9 个月的时间里，囊肿开始逐渐增大。在手术前的初步检查中，我们在胸腰部观察到一个直径约为 60 * 70 * 40 厘米的巨大皮肤包裹骨髓囊肿囊。手术期间从囊肿中引流出 20 多升脑脊液：教训：囊肿增大的机制尚不十分清楚。即使没有脑积水，未修复的骨髓囊肿囊肿也有可能在老年期逐渐严重增大。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.