Hefeng Tian, Hui Li, Xuanrui Zhu, Wenlong Liu, Ying Fan, Lei Shi, Xiu Wang
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引用次数: 0
Abstract
Methods: A total of 120 patients were randomized to receive either the control group (n = 64) or the experimental group (n = 65). Patients in the control group adopted the low-volume split-dose regimen one, and patients in the experimental group adopted the low-volume split-dose regimen two. Those randomized to regimen one were instructed to take 0.75 L PEG two hours after dinner the day before the colonoscopy and 1.5 L PEG 4 hours before the colonoscopy. Patients assigned to regimen two were invited to consume 1.5 L PEG two hours after dinner the day before the colonoscopy and 0.75 L PEG 4 hours before the colonoscopy. The quality of bowel preparation, rated according to a Boston Bowel Preparation Scale (BBPS), represented the primary outcome measure. Tolerability, satisfaction, and lesions detection rated were secondary outcomes.
Results: There was no significant difference between the transverse colon and right colon scores between the two groups (P > 0.05). The low-volume split-dose regimen two showed a higher success rate for cleansing of the right colon and overall colon (P < 0.05). For the comparison of the patients' bowel tolerance, there were no statistical differences between the two groups regarding thirst, abdominal pain or abdominal discomfort, abdominal distension, dizziness or headache, anal discomfort, and sleep disturbance (P > 0.05). However, regimen two had significantly less nausea, vomiting, and fatigue than regimen one (24.62% vs. 42.19%, P=0.034; 10.77% vs. 25.00%, P=0.035; 6.15% vs. 21.88%, P=0.010, respectively). Patient-reported satisfaction and willingness to repeat the bowel preparation were significantly higher for low-volume split-dose regimen two than for low-volume split-dose regimen one (P=0.011; P=0.015).
Conclusions: In early morning colonoscopies, the bowel-cleansing efficacy and patient tolerability of low-volume split-dose regimen two were superior to low-volume split-dose regimen one.
方法:120例患者随机分为对照组(n = 64)和实验组(n = 65)。对照组采用小体积分次给药方案一，实验组采用小体积分次给药方案二。随机分配到方案一的患者在结肠镜检查前一天晚餐后2小时服用0.75 L PEG，结肠镜检查前4小时服用1.5 L PEG。分配到方案二的患者在结肠镜检查前一天晚餐后2小时摄入1.5 L PEG，在结肠镜检查前4小时摄入0.75 L PEG。根据波士顿肠道准备量表(BBPS)进行评级的肠道准备质量代表了主要的结局指标。耐受性、满意度和病变检出率是次要结果。结果:两组患者横结肠、右结肠评分差异无统计学意义(P > 0.05)。小体积分次给药方案二对右结肠和全结肠的清洗成功率较高(P < 0.05)。比较两组患者的肠道耐受性，两组在口渴、腹痛或腹部不适、腹胀、头晕或头痛、肛门不适、睡眠障碍等方面差异无统计学意义(P > 0.05)。然而，方案2的恶心、呕吐和疲劳明显少于方案1 (24.62% vs. 42.19%， P=0.034;10.77% vs. 25.00%， P=0.035;6.15% vs. 21.88%， P=0.010)。患者报告的满意度和重复肠准备的意愿在小体积分剂量方案2中显著高于小体积分剂量方案1 (P=0.011;P = 0.015)。结论:在清晨结肠镜检查中，小剂量分次方案2的清肠效果和患者耐受性优于小剂量分次方案1。
期刊介绍：
Canadian Journal of Gastroenterology and Hepatology is a peer-reviewed, open access journal that publishes original research articles, review articles, and clinical studies in all areas of gastroenterology and liver disease - medicine and surgery.
The Canadian Journal of Gastroenterology and Hepatology is sponsored by the Canadian Association of Gastroenterology and the Canadian Association for the Study of the Liver.
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