A Case of Priapism in a Child With Autism Spectrum Disorder, Possibly Due to Risperidone Treatment With Addition of Atomoxetine.

IF 0.8 4区医学 Q4 CLINICAL NEUROLOGY Clinical Neuropharmacology Pub Date : 2022-11-01 Epub Date: 2022-09-11 DOI:10.1097/WNF.0000000000000524

Ömer Faruk Bulut, Yaşar Tanir

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引用次数: 0

Abstract

Objectives: Risperidone is an effective drug used for the treatment of irritability in children with autism spectrum disorder (ASD). Atomoxetine (ATX) is a well-tolerated drug used in first-line therapy in children with attention-deficit/hyperactivity disorder (ADHD). However, uncommon adverse effects of risperidone and ATX are a concern among mental health professionals. To our knowledge, this is the first case report of priapism after addition of ATX upon existing treatment with risperidone.

Methods: Written informed consent for publication was obtained from the patient and his parents, and their identities were concealed for ethical reasons.

Results: Here, we report a case of priapism as an adverse effect of ATX and risperidone treatment in a 7-year-old boy with ASD and comorbid ADHD. In this case, priapism was not observed with risperidone until ATX was added.

Conclusions: Priapism is a condition viewed as a medical emergency. Although risperidone-induced priapism is a rare phenomenon, it is advised for clinicians to consider the drug interactions in treatment of ASD and ADHD in terms of early diagnosis and intervention.

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孤独症谱系障碍儿童阴茎勃起1例，可能是利培酮加托莫西汀所致。

目的:利培酮是一种治疗自闭症谱系障碍(ASD)患儿易怒的有效药物。托莫西汀(ATX)是一种耐受性良好的药物，用于儿童注意力缺陷/多动障碍(ADHD)的一线治疗。然而，利培酮和ATX不常见的不良反应是心理健康专业人员关注的问题。据我们所知，这是第一例在利培酮治疗基础上加用ATX后出现阴茎勃起的病例报告。方法:获得患者及其父母的书面知情同意发表，出于伦理原因对其身份进行保密。结果:在这里，我们报告了一个7岁男孩ASD和共病ADHD的ATX和利培酮治疗的不良反应勃起。在加入ATX之前，利培酮未观察到阴茎勃起。结论:阴茎勃起是一种被视为医学急症的疾病。虽然利培酮引起的阴茎勃起是一种罕见的现象，但建议临床医生在治疗ASD和ADHD的早期诊断和干预方面考虑药物相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neuropharmacology 医学-临床神经学

CiteScore

1.20

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Neuropharmacology is a peer-reviewed journal devoted to the pharmacology of the nervous system in its broadest sense. Coverage ranges from such basic aspects as mechanisms of action, structure-activity relationships, and drug metabolism and pharmacokinetics, to practical clinical problems such as drug interactions, drug toxicity, and therapy for specific syndromes and symptoms. The journal publishes original articles and brief reports, invited and submitted reviews, and letters to the editor. A regular feature is the Patient Management Series: in-depth case presentations with clinical questions and answers.