Diagnostic and prognostic potential of the resident non-small cell lung cancer microbiome.

Q4 Health Professions Klinichescheskaya Laboratornaya Diagnostika Pub Date : 2022-08-15 DOI:10.51620/0869-2084-2022-67-8-458-462

Olga Vladimirovna Kovaleva, N E Kushlinskii, P A Podlesnaya, I S Stilidi, A N Gratchev

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Abstract

The data of a comprehensive comparative study of the taxonomic composition of the resident microbiome of tumors from 26 patients with non-small cell lung cancer are presented. Analysis of taxonomic diversity revealed 10 types, 280 genera and 788 species of microorganisms. The analysis of the relative content and prognostic significance was carried out for 62 dominant genera. Differences in the relative abundance of bacteria of the genera Acinetobacter, Halomonas, and Chryseobacterium between tumor and conditionally normal lung tissue were found, but their diagnostic potential was not confirmed. The correlation analysis did not reveal any relationship between the content of various genera of bacteria and the histological type of the tumor, its localization, and the age of the patients. Differences were found in the content of the studied bacteria depending on the stage of the disease, the presence of regional metastases and tumor differentiation. The prognostic significance of bacteria of the genera Variovorax and Pseudoclavibacter in non-small cell lung cancer was established. The results obtained can be used in the development of new effective methods for the diagnosis and prognosis of non-small cell lung cancer.

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常住非小细胞肺癌微生物组的诊断和预后潜力。

对26例非小细胞肺癌患者肿瘤常驻微生物组的分类组成进行了全面的比较研究。分类多样性分析发现微生物有10种280属788种。对62个优势属进行相对含量分析及预后意义分析。在肿瘤和条件正常肺组织中发现了不动杆菌属、盐单胞菌属和黄杆菌属细菌的相对丰度差异，但其诊断潜力尚未得到证实。相关分析未发现各属细菌的含量与肿瘤的组织学类型、肿瘤的定位和患者的年龄之间存在任何关系。根据疾病的分期、区域转移的存在和肿瘤分化，发现所研究细菌的含量存在差异。建立了异卵杆菌属和假锁骨杆菌属细菌在非小细胞肺癌中的预后意义。所得结果可用于开发新的有效的非小细胞肺癌的诊断和预后方法。

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来源期刊

Klinichescheskaya Laboratornaya Diagnostika Health Professions-Medical Laboratory Technology

CiteScore

0.90

自引率

0.00%

发文量

110

期刊介绍： The journal deals with theoretical and practical problems of clinical laboratory diagnosis, publishes editorial articles, reviews of literature, original articles, short reports, discussions, book reviews, current events, materials which may assist the practitioners, methods of laboratory investigations used in medicine, materials on the results of practical application of new methods of investigation in the following fields of clinical laboratory diagnosis: hematology, cytology, coagulation, biochemistry, immunology.