An insight into the placental growth factor (PlGf)/angii axis in Covid-19: a detrimental intersection.

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY ACS Applied Nano Materials Pub Date : 2024-12-01 Epub Date: 2022-09-12 DOI:10.1080/02648725.2022.2122291

Hayder M Al-Kuraishy, Ali I Al-Gareeb, Thabat J Al-Maiahy, Athanasios Alexiou, Nobendu Mukerjee, Gaber El-Saber Batiha

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Abstract

Coronavirus disease 2019 (Covid-19) is a recent and current infectious pandemic caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). Covid-19 may lead to the development of acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and extrapulmonary manifestations in severe cases. Down-regulation of angiotensin-converting enzyme (ACE2) by the SARS-CoV-2 increases the production of angiotensin II (AngII), which increases the release of pro-inflammatory cytokines and placental growth factor (PlGF). PlGF is a critical molecule involved in vasculogenesis and angiogenesis. PlGF is stimulated by AngII in different inflammatory diseases through a variety of signaling pathways. PlGF and AngII are interacted in SARS-CoV-2 infection resulting in the production of pro-inflammatory cytokines and the development of Covid-19 complications. Both AngII and PlGF are interacted and are involved in the progression of inflammatory disorders; therefore, we aimed in this review to highlight the potential role of the PlGF/AngII axis in Covid-19.

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洞察 Covid-19 中的胎盘生长因子（PlGf）/angii 轴：有害的交叉点。

冠状病毒病 2019（Covid-19）是由严重急性呼吸系统综合征冠状病毒 2 型（SARS-CoV-2）引起的近期和当前的传染性流行病。Covid-19可能导致急性肺损伤（ALI）、急性呼吸窘迫综合征（ARDS）的发生，严重病例还可能出现肺外表现。SARS-CoV-2 对血管紧张素转换酶（ACE2）的下调增加了血管紧张素 II（AngII）的产生，从而增加了促炎细胞因子和胎盘生长因子（PlGF）的释放。PlGF 是参与血管生成和血管生成的重要分子。在不同的炎症性疾病中，AngII 会通过多种信号通路刺激 PlGF。在 SARS-CoV-2 感染中，PlGF 和 AngII 相互作用，导致促炎细胞因子的产生和 Covid-19 并发症的发生。AngII 和 PlGF 相互作用并参与炎症性疾病的进展；因此，我们在本综述中旨在强调 PlGF/AngII 轴在 Covid-19 中的潜在作用。

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来源期刊

ACS Applied Nano Materials Multiple-

CiteScore

8.30

自引率

3.40%

发文量

1601

期刊介绍： ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.