Trace Element Concentration and Cognitive Dysfunction in Elderly Residents in Birjand.

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-01-01 DOI:10.2174/1567205019666220913114154

Toba Kazemi, Mitra Moodi, Shahnaz Rajabi, Farshad Sharifi, Saeed Samarghandian, Masoumeh Khorashadizadeh, Tahereh Farkhondeh

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Abstract

Background: Trace elements were suggested to have a main role in modulating cognitive function. However, there are several controversial findings regarding the association between serum trace element concentration and cognitive function in patients with cognitive disorders.

Methods: Thus, this study aimed to evaluate the changes in serum trace element concentrations in elderly with cognitive dysfunction versus the participants with normal cognitive function. This crosssectional study included 191 older adults over 60 years from Birjand County, Iran. Participants were assessed for cognitive performance and serum trace elements concentration, including aluminum (AL), cobalt (Co), cadmium (Cd), Chrome (Cr), copper (Cu), Iron (Fe), magnesium (Mg), manganese (Mn), selenium (Se) and zinc (Zn). Our findings showed no significant difference in the serum concentration of AL, Co, Cr, Zn, Fe, Mg, Mn, and Se of elderly with cognitive dysfunction versus the subjects with normal cognitive function.

Results: However, the concentration of Cu significantly increased in the serum of the elderly with cognitive dysfunction versus participants with normal function. In conclusion, our study indicated an increase in the serum concentration of Cu in the elderly with cognitive dysfunction in the sample of the Birjand Longitudinal Aging Study.

Conclusion: However, due to the main limitations of our study, including low sample size and crosssection design, these findings should be interpreted with caution.

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比尔詹德老年居民的微量元素浓度和认知功能障碍。

微量元素被认为在调节认知功能方面发挥着主要作用。然而，关于认知障碍患者血清中微量元素浓度与认知功能之间的关系，目前还存在一些争议。因此，本研究旨在评估认知功能障碍老年人与认知功能正常者血清微量元素浓度的变化。这项横断面研究包括来自伊朗比尔詹德县的 191 名 60 岁以上的老年人。研究人员对参与者的认知能力和血清微量元素浓度进行了评估，包括铝（AL）、钴（Co）、镉（Cd）、铬（Cr）、铜（Cu）、铁（Fe）、镁（Mg）、锰（Mn）、硒（Se）和锌（Zn）。我们的研究结果表明，患有认知功能障碍的老人与认知功能正常的老人相比，其血清中的AL、Co、Cr、Zn、Fe、Mg、Mn和Se的浓度没有明显差异。然而，与认知功能正常的受试者相比，认知功能障碍老年人血清中铜的浓度明显升高。总之，我们的研究表明，在比尔詹德老龄化纵向研究的样本中，认知功能障碍老年人血清中的铜浓度有所增加。然而，由于我们的研究存在样本量少和横断面设计等主要局限性，因此在解释这些发现时应谨慎。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.