Survival outcomes of the combination of extrafascial extrahepatic and extrafascial intrahepatic pedicle approaches in hepatectomy for hepatocellular carcinoma.

IF 1.5 Q3 GASTROENTEROLOGY & HEPATOLOGY Clinical and Experimental Hepatology Pub Date : 2022-06-01 Epub Date: 2022-05-26 DOI:10.5114/ceh.2022.116156
Toan Huy Nguyen, Quyet Van Ha, Huong Van Nguyen, Duyet Van Pham, Thuong Van Pham, Thanh Van Le, Xuan Anh Le, Ai Quoc Dang
{"title":"Survival outcomes of the combination of extrafascial extrahepatic and extrafascial intrahepatic pedicle approaches in hepatectomy for hepatocellular carcinoma.","authors":"Toan Huy Nguyen,&nbsp;Quyet Van Ha,&nbsp;Huong Van Nguyen,&nbsp;Duyet Van Pham,&nbsp;Thuong Van Pham,&nbsp;Thanh Van Le,&nbsp;Xuan Anh Le,&nbsp;Ai Quoc Dang","doi":"10.5114/ceh.2022.116156","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>This study was conducted to evaluate the results of hepatectomy for hepatocellular carcinoma (HCC) by the combination of extrafascial extrahepatic (Takasaki method) and extrafascial intrahepatic pedicle approaches (Ton That Tung method).</p><p><strong>Material and methods: </strong>A longitudinal follow-up study was conducted on 83 patients undergoing hepatectomy for HCC using the combination of extrafascial extrahepatic (Takasaki method) and extrafascial intrahepatic pedicle approaches at Nghe An Provincial Hospital from April 2017 to July 2021. Survival analysis was applied.</p><p><strong>Results: </strong>The cumulative overall survival (OS) rates after 1, 2, 3 and 4 years were 88.4%, 76.3%, 69.5% and 56.9%, respectively. The mean OS time was 40.68 ±2.17 months. The 1-, 2-, 3- and 4-year disease-free survival (DFS) rates were 67.1%, 56%, 53.1% and 50%, respectively. The mean DFS time was 32.58 ±2.56 months. Surgical margin > 1 cm was an independent predictor of both overall and disease-free survival (HR = 5.194, 95% CI = 1.467-18,385, <i>p</i> = 0.011 for OS; HR = 2.822, 95% CI = 1.231-6.468, <i>p</i> = 0.014 for DFS).</p><p><strong>Conclusions: </strong>Hepatectomy for HCC by a combination of extrafascial extrahepatic (Takasaki method) and extrafascial intrahepatic pedicle approaches (Ton That Tung method) is effective and safe, and side effects and complications can be controlled. Patient selection is a key issue and plays a very important role in the outcome of treatment.</p>","PeriodicalId":10281,"journal":{"name":"Clinical and Experimental Hepatology","volume":"8 2","pages":"147-152"},"PeriodicalIF":1.5000,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c0/cc/CEH-8-47009.PMC9442654.pdf","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Experimental Hepatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5114/ceh.2022.116156","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/5/26 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 1

Abstract

Introduction: This study was conducted to evaluate the results of hepatectomy for hepatocellular carcinoma (HCC) by the combination of extrafascial extrahepatic (Takasaki method) and extrafascial intrahepatic pedicle approaches (Ton That Tung method).

Material and methods: A longitudinal follow-up study was conducted on 83 patients undergoing hepatectomy for HCC using the combination of extrafascial extrahepatic (Takasaki method) and extrafascial intrahepatic pedicle approaches at Nghe An Provincial Hospital from April 2017 to July 2021. Survival analysis was applied.

Results: The cumulative overall survival (OS) rates after 1, 2, 3 and 4 years were 88.4%, 76.3%, 69.5% and 56.9%, respectively. The mean OS time was 40.68 ±2.17 months. The 1-, 2-, 3- and 4-year disease-free survival (DFS) rates were 67.1%, 56%, 53.1% and 50%, respectively. The mean DFS time was 32.58 ±2.56 months. Surgical margin > 1 cm was an independent predictor of both overall and disease-free survival (HR = 5.194, 95% CI = 1.467-18,385, p = 0.011 for OS; HR = 2.822, 95% CI = 1.231-6.468, p = 0.014 for DFS).

Conclusions: Hepatectomy for HCC by a combination of extrafascial extrahepatic (Takasaki method) and extrafascial intrahepatic pedicle approaches (Ton That Tung method) is effective and safe, and side effects and complications can be controlled. Patient selection is a key issue and plays a very important role in the outcome of treatment.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
筋膜外肝外和筋膜外肝内蒂联合入路在肝细胞癌肝切除术中的生存结果。
简介:本研究旨在评价筋膜外肝外入路(Takasaki法)和筋膜外肝内蒂入路(Ton That Tung法)联合行肝细胞癌(HCC)肝切除术的效果。材料和方法:对2017年4月至2021年7月在义安省医院采用筋膜外肝外(Takasaki法)和筋膜外肝内蒂联合入路行HCC肝切除术的83例患者进行了纵向随访研究。采用生存分析。结果:1年、2年、3年、4年累积总生存率(OS)分别为88.4%、76.3%、69.5%、56.9%。平均OS时间40.68±2.17个月。1年、2年、3年和4年无病生存率(DFS)分别为67.1%、56%、53.1%和50%。平均DFS时间为32.58±2.56个月。手术切缘> 1 cm是总生存率和无病生存率的独立预测因子(HR = 5.194, 95% CI = 1.467- 18385, p = 0.011);DFS的HR = 2.822, 95% CI = 1.231 ~ 6.468, p = 0.014)。结论:经筋膜外肝外入路(Takasaki法)和筋膜外肝内蒂入路(tonthat Tung法)联合行HCC肝切除术有效、安全,副作用及并发症可控。患者选择是一个关键问题,对治疗结果起着非常重要的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Clinical and Experimental Hepatology
Clinical and Experimental Hepatology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
2.80
自引率
0.00%
发文量
32
期刊介绍: Clinical and Experimental Hepatology – quarterly of the Polish Association for Study of Liver – is a scientific and educational, peer-reviewed journal publishing original and review papers describing clinical and basic investigations in the field of hepatology.
期刊最新文献
Bone marrow mesenchymal stem cell-originated exosomes suppress activation of hepatic stellate cells through the miR-144-3p/SLC7A11 axis. Commonly available dietary supplements, herbs and medicines - do they pose a risk for liver health? Literature review in the context of the Polish population. Echinococcosis of the liver in Poland - review of the literature and our own clinical material. Effectiveness of glecaprevir/pibrentasvir in HIV/HCV-coinfected patients treated with bictegravir/emtricitabine/tenofovir alafenamide. Multifocality in gallbladder cancer: An imaging-based study.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1