Comparing the Effects of Pregabalin and Clonidine on Postoperative Pain in Tonsillectomy: A Randomized, Double-Blind, Prospective Clinical Trial.

IF 1.4 Q4 PHARMACOLOGY & PHARMACY Reviews on recent clinical trials Pub Date : 2022-09-22 DOI:10.2174/1574887117666220922092953

Shahryar Sane, Rahman Abbasi Vash, Nazila Rahmani, Hadi Talebi, Parang Golabi, Farid Kalashipour, Poneh Heidari, Mohammad-Foad Hatami, Behzad Kazemi Haki, Shabnam Morwati

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Abstract

Background: Tonsillectomy is one of the most common surgical procedures. This study compared the effect of Pregabalin and Clonidine on postoperative pain in adult patients undergoing elective tonsillectomy.

Methods: This randomized, double-blind, prospective clinical trial was conducted among 92 patients aged 20 to 50. The clonidine group (C) was given 150 µg of clonidine tablet 90 minutes before surgery, and the pregabalin group (P) was given 300 mg of pregabalin tablet 90 minutes before surgery. The results were analyzed by SPSS 25, and statistical analysis consisted of chisquare, T-test, and χ2 tests, and a p-value less than 0.05 was considered significant.

Results: The mean pain score and analgesic consumption scores in the pregabalin group were lower than in the clonidine group. According to the t-test, there was a significant difference between the two groups regarding pain score and analgesic consumption (p <0.05). Hemodynamic variation in both groups had no significant differences (p >0.05).

Conclusion: The present study showed that pregabalin reduced postoperative pain and analgesic consumption more effectively than clonidine.

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比较普瑞巴林和氯硝柳胺对扁桃体切除术术后疼痛的影响：随机、双盲、前瞻性临床试验。

背景：扁桃体切除术是最常见的外科手术之一：扁桃体切除术是最常见的外科手术之一。本研究比较了普瑞巴林和氯硝柳胺对接受扁桃体切除术的成年患者术后疼痛的影响：这项随机、双盲、前瞻性临床试验在 92 名 20 至 50 岁的患者中进行。克洛尼定组（C）在手术前 90 分钟服用 150 微克克洛尼定片，普瑞巴林组（P）在手术前 90 分钟服用 300 毫克普瑞巴林片。结果采用 SPSS 25 进行分析，统计分析包括方差分析、T 检验和 χ2 检验，P 值小于 0.05 为差异有显著性：普瑞巴林组的平均疼痛评分和镇痛药消耗评分均低于氯硝柳胺组。根据 t 检验，两组在疼痛评分和镇痛药消耗量方面存在显著差异（P 0.05）：本研究表明，普瑞巴林比氯尼替丁更有效地减轻了术后疼痛和镇痛药用量。

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来源期刊

Reviews on recent clinical trials PHARMACOLOGY & PHARMACY-

CiteScore

3.10

自引率

5.30%

发文量

期刊介绍： Reviews on Recent Clinical Trials publishes frontier reviews on recent clinical trials of major importance. The journal"s aim is to publish the highest quality review articles in the field. Topics covered include: important Phase I – IV clinical trial studies, clinical investigations at all stages of development and therapeutics. The journal is essential reading for all researchers and clinicians involved in drug therapy and clinical trials.