Association between serum midkine levels and tumor size in Indonesian hepatocellular carcinoma patients: a cross-sectional study.

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Romanian Journal of Internal Medicine Pub Date : 2022-11-23 Print Date: 2022-12-01 DOI:10.2478/rjim-2022-0014
Darmadi Darmadi, Riska Habriel Ruslie, Cennikon Pakpahan
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引用次数: 1

Abstract

Background: The incidence of liver cancer is increased worldwide with 75%-85% diagnosed as hepatocellular carcinoma (HCC). Current practice has low sensitivity limitations to diagnose the early stages of HCC, thus urging the need for a biomarker with higher sensitivity to detect HCC, specifically in the early stage. This study aimed to determine the association between midkine levels and progressiveness of hepatocellular carcinoma (HCC), according to tumor size, Barcelona Clinic Liver Cancer (BCLC), and presence of portal venous thrombosis. Methods: This cross-sectional study involved 100 patients in Adam Malik General Hospital diagnosed with HCC, collected with a consecutive sampling method, whose diagnoses were confirmed by findings of hypervascular on arterial phase imaging and portal vein or delayed phase washout triple-phase CT Scan. Samples are later categorized according to Barcelona Clinic Liver Cancer (BCLC) stages, tumor size, and presence of portal venous thrombosis. Blood samples were drawn to measure serum midkine using ELISA. Kruskal-Wallis and Mann-Whitney U tests were conducted to determine the difference of midkine levels based on tumor size, BCLC staging, and presence of portal venous thrombosis. Results: Serum midkine level shows a significant difference over tumor size (p=0.014), no significant difference found compared to BCLC stages and presence of portal venous thrombosis. Conclusion: Serum midkine levels are associated with the tumor size of HCC, thus helping physicians determine treatment plans.

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印度尼西亚肝细胞癌患者血清midkine水平与肿瘤大小之间的关系:一项横断面研究。
背景:肝癌的发病率在全球范围内呈上升趋势,其中75%-85%诊断为肝细胞癌(HCC)。目前的实践对早期HCC的诊断存在低灵敏度的限制,因此迫切需要更高灵敏度的生物标志物来检测HCC,特别是在早期。本研究旨在根据肿瘤大小、巴塞罗那临床肝癌(BCLC)和门静脉血栓形成情况,确定midkine水平与肝细胞癌(HCC)进展之间的关系。方法:本横断面研究纳入亚当马利克总医院诊断为HCC的100例患者,采用连续抽样的方法,通过动脉期成像和门静脉或延迟期冲洗三期CT扫描发现血管增生证实诊断。样本随后根据巴塞罗那诊所肝癌(BCLC)分期、肿瘤大小和是否存在门静脉血栓进行分类。抽取血样,采用ELISA法测定血清midkine。采用Kruskal-Wallis和Mann-Whitney U试验来确定基于肿瘤大小、BCLC分期和门静脉血栓形成的midkine水平的差异。结果:血清midkine水平与肿瘤大小有显著性差异(p=0.014),与BCLC分期及是否存在门静脉血栓无显著性差异。结论:血清midkine水平与肝癌肿瘤大小有关,有助于医生确定治疗方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Romanian Journal of Internal Medicine
Romanian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
5.30%
发文量
35
审稿时长
15 weeks
期刊介绍: Romanian Journal of Physics is a journal publishing physics contributions on the following themes: •Theoretical Physics & Applied Mathematics •Nuclear Physics •Solid State Physics & Materials Science •Statistical Physics & Quantum Mechanics •Optics •Spectroscopy •Plasma & Lasers •Nuclear & Elementary Particles Physics •Atomic and Molecular Physics •Astrophysics •Atmosphere and Earth Science •Environment Protection
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