Crohn's Disease with Fistula: 10 Year Trends and Mortality in the United States.

IF 0.6 Q4 GASTROENTEROLOGY & HEPATOLOGY The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2022-09-25 DOI:10.4166/kjg.2022.061
Hassam Ali, Rizwan Ishtiaq, Muhammad Waqar Hanif, Rahul Pamarthy, Muhammad Hassan Farooq, Muhammad Fahd Farooq
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Abstract

Background/aims: Crohn's disease (CD) results in significant morbidity, mortality, and healthcare burden. This study evaluated the temporal trends of CD hospitalizations with a fistula over the last decade to understand the outcomes of severe CD.

Methods: National Inpatient Sample database from 2009 to 2019 was used to identify CD hospitalizations with a fistula. The outcomes of interest included temporal trend analysis of length of stay (LOS), mean inpatient cost (MIC), and mortality.

Results: There was an increase in the total number of fistulizing CD hospitalizations from 5,386 in 2009 to 12,900 in 2019 (p<0.01). The mean age decreased from 44.9±0.6 to 41.8±0.4 years for the study period (p<0.01). Caucasians were the predominant ethnicity, followed by Africans, Hispanics, and others (p<0.001). The mean LOS for fistulizing CD hospitalizations decreased significantly from 11.57±0.09 days in 2009 to 7.20±0.05 days in 2019 (p<0.001). There was a significant decrease in inpatient mortality from 1.72% in 2009 to 0.73% in 2019 (p<0.01). The MIC did not have a significant trend. There was a decreasing trend toward partial/total colectomies, rectosigmoid, and small bowel surgeries from 2009 to 2019 (p<0.001).

Conclusions: There has been a rise in CD hospitalizations with fistulizing disease in the last decade. Despite this, the mortality and inpatient LOS have been decreasing significantly. In addition, the increase in CD hospitalizations with fistulizing disease has had no significant effect on hospital costs.

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克罗恩病伴瘘管:美国10年趋势和死亡率
背景/目的:克罗恩病(CD)导致显著的发病率、死亡率和医疗负担。本研究评估了过去十年中伴有瘘管的CD住院的时间趋势,以了解严重CD的结局。方法:使用2009年至2019年的国家住院患者样本数据库来识别伴有瘘管的CD住院。研究结果包括住院时间(LOS)、平均住院费用(MIC)和死亡率的时间趋势分析。结果:瘘管性CD住院总人数从2009年的5386人增加到2019年的12900人(结论:在过去十年中,瘘管性疾病的CD住院人数有所增加。尽管如此,死亡率和住院LOS一直在显著下降。此外,伴有瘘管性疾病的乳糜泻住院率的增加对医院费用没有显著影响。
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CiteScore
1.20
自引率
0.00%
发文量
83
审稿时长
24 weeks
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