{"title":"<i>Cinchona</i> bark and quinine in the Portuguese official pharmacopoeias (1794-2001).","authors":"M G Semedo, A L Pereira, J R Pita","doi":"10.1691/ph.2022.2034","DOIUrl":null,"url":null,"abstract":"<p><p><i>Cinchona</i> bark (bark from plants of the genus <i>Cinchona</i> with antimalarial activity) and its alkaloid quinine were widely used to treat intermittent fevers. This paper aims to quantitatively analyze the presence of <i>Cinchona</i> bark, quinine and other <i>Cinchona</i> bark-derived substances in the Portuguese official pharmacopoeias published between 1794 and 2001. The analysis showed that the <i>Pharmacopêa Portugueza</i> (1876) is the Portuguese official pharmacopeia with the highest percentage of medicines containing <i>Cinchona</i> bark (2.61%). The <i>Farmacopeia Portuguesa IV</i> (1935) is the official pharmacopeia with the highest percentage of quinine-containing medicines (2.34%). Medicines made from <i>Cinchona</i> bark are present in the Portuguese official pharmacopoeias until the <i>Farmacopeia Portuguesa IV</i> (1946). Medicines made from quinine have been present in Portuguese official pharmacopoeias since the <i>Codigo Pharmaceutico Lusitano</i> (1835).</p>","PeriodicalId":20145,"journal":{"name":"Pharmazie","volume":"77 7","pages":"278-285"},"PeriodicalIF":1.5000,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmazie","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1691/ph.2022.2034","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
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Abstract
Cinchona bark (bark from plants of the genus Cinchona with antimalarial activity) and its alkaloid quinine were widely used to treat intermittent fevers. This paper aims to quantitatively analyze the presence of Cinchona bark, quinine and other Cinchona bark-derived substances in the Portuguese official pharmacopoeias published between 1794 and 2001. The analysis showed that the Pharmacopêa Portugueza (1876) is the Portuguese official pharmacopeia with the highest percentage of medicines containing Cinchona bark (2.61%). The Farmacopeia Portuguesa IV (1935) is the official pharmacopeia with the highest percentage of quinine-containing medicines (2.34%). Medicines made from Cinchona bark are present in the Portuguese official pharmacopoeias until the Farmacopeia Portuguesa IV (1946). Medicines made from quinine have been present in Portuguese official pharmacopoeias since the Codigo Pharmaceutico Lusitano (1835).
期刊介绍：
The journal DiePharmazie publishs reviews, experimental studies, letters to the editor, as well as book reviews.
The following fields of pharmacy are covered:
Pharmaceutical and medicinal chemistry;
Pharmaceutical analysis and drug control;
Pharmaceutical technolgy;
Biopharmacy (biopharmaceutics, pharmacokinetics, biotransformation);
Experimental and clinical pharmacology;
Pharmaceutical biology (pharmacognosy);
Clinical pharmacy;
History of pharmacy.
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