Flow Resistance Analysis of Clinically Significant Portal Hypertension in Patients with Liver Cirrhosis.

IF 2.7 4区 医学 Q2 Medicine Canadian Journal of Gastroenterology and Hepatology Pub Date : 2022-09-26 eCollection Date: 2022-01-01 DOI:10.1155/2022/9396371
Yizhe Wang, Luxiang Zhao, Zhuozhao Zheng, Yu Zhang
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Abstract

Cirrhosis-induced clinically significant portal hypertension (CSPH) is a fatal disease. Early detection of CSPH is vitally important to reduce the patients' mortality rate. In this study, combined with three-dimensional image construction technology and computational fluid dynamics (CFD), an image-based flow resistance analysis was proposed. The flow resistance analysis was performed for nine cirrhosis patients with CSPH and ten participants without liver diseases, respectively. The results showed that the flow resistance coefficient of the portal vein system in CSPH patients was significantly lower than that in the control group (0.97 ± 0.11 Pa/(mL/s) for CSPH patients; 1.80 ± 0.40 Pa/(mL/s) for the control group; P = 0.028). In contrast, although main portal vein dilation was found in CSPH patients, the cross-sectional area enlargement was not statistically significant (186.01 ± 57.48 mm2 for CSPH patients; 166.26 ± 33.74 mm2 for the control group; P = 0.39). The research outcomes indicated that the flow resistance analysis was more sensitive than the commonly used vessel size measurement in the detection of CSPH. In summary, we suggest using flow resistance analysis as a supplementary noninvasive method to detect cirrhosis patients with CSPH.

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肝硬化患者门静脉高压的血流阻力分析。
肝硬化引起的临床显著性门脉高压(CSPH)是一种致命的疾病。早期发现CSPH对降低患者死亡率至关重要。本研究将三维图像构建技术与计算流体力学(CFD)相结合,提出了一种基于图像的流阻分析方法。分别对9例肝硬化合并CSPH患者和10例无肝脏疾病的参与者进行了血流阻力分析。结果表明:CSPH患者门静脉系统血流阻力系数显著低于对照组(0.97±0.11 Pa/(mL/s));对照组为1.80±0.40 Pa/(mL/s);P = 0.028)。相比之下,CSPH患者门静脉主干扩张,但横截面积扩大无统计学意义(186.01±57.48 mm2);对照组为166.26±33.74 mm2;P = 0.39)。研究结果表明,在CSPH检测中,流动阻力分析比常用的血管尺寸测量更敏感。综上所述,我们建议将血流阻力分析作为一种辅助的无创方法来检测肝硬化合并CSPH患者。
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来源期刊
CiteScore
4.80
自引率
0.00%
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0
审稿时长
37 weeks
期刊介绍: Canadian Journal of Gastroenterology and Hepatology is a peer-reviewed, open access journal that publishes original research articles, review articles, and clinical studies in all areas of gastroenterology and liver disease - medicine and surgery. The Canadian Journal of Gastroenterology and Hepatology is sponsored by the Canadian Association of Gastroenterology and the Canadian Association for the Study of the Liver.
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