Quantitative serum determination of CD3, CD4, CD8, CD16, and CD56 in women with primary infertility: The role of cell-mediated immunity.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-09-23 DOI:10.4274/tjod.galenos.2022.47527

Behzad Shakerian, Sahar Irvani, Sara Mostafavi, Mozhgan Moghtaderi

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Abstract

Objective: Cellular adaptive immunity plays an essential role in the etiology of primary infertility. This study aimed to measure the T-lymphocyte subpopulations and natural killer (NK) cells in infertile women compared with healthy ones.

Materials and methods: From January to September 2021, we conducted this cross-sectional study among women with primary infertility, and healthy women were referred to Isfahan Fertility and Infertility Center affiliated with Najafabad University of medical sciences in Isfahan, Iran for immunological investigations. For each person, we determined quantitative serum measurements of CD3, CD4, CD8, CD4/CD8, CD16, CD56, and CD56+16.

Results: This study included one hundred and fifty-one infertile women with a mean age of 31.4±4.7 years and 46 healthy women with a mean age of 31.5±3.4 years. Compared to the controls, immunophenotyping findings in infertile patients revealed a significant drop in CD8 T cells [p=0.01, 95% confidence interval (CI) 0.53 to 4.57] and the percentage of CD 56 NK cells (p=0.005, 95% CI 0.74 to 4.03) in infertile patients.

Conclusion: Despite having a normal quantity of CD3 T cells, infertile women had lower CD8 T cells and CD56 NK cells than the controls. More studies are needed to confirm the role of cell-mediated assessments as a screening test in patients with primary infertility.

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原发性不孕症妇女血清CD3、CD4、CD8、CD16和CD56的定量测定:细胞介导免疫的作用

目的:细胞适应性免疫在原发性不孕症的病因学中起重要作用。本研究旨在测定不孕妇女与健康妇女的t淋巴细胞亚群和自然杀伤(NK)细胞。材料和方法:我们于2021年1月至9月在原发性不孕症妇女中进行了这项横断面研究，健康妇女被转介到伊朗伊斯法罕纳贾法巴德医科大学附属的伊斯法罕生育和不孕症中心进行免疫学调查。对于每个人，我们测定了CD3、CD4、CD8、CD4/CD8、CD16、CD56和CD56+16的定量血清测量值。结果:纳入151例不孕妇女，平均年龄31.4±4.7岁;46例健康妇女，平均年龄31.5±3.4岁。与对照组相比，不孕症患者的免疫表型结果显示CD8 T细胞显著下降[p=0.01, 95%可信区间(CI) 0.53至4.57]，cd56 NK细胞百分比显著下降(p=0.005, 95% CI 0.74至4.03)。结论:尽管CD3 T细胞数量正常，但不孕妇女的CD8 T细胞和CD56 NK细胞均低于对照组。需要更多的研究来证实细胞介导的评估作为原发性不孕症患者筛查试验的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.