Diagnostic signature and immune characteristic of aging-related genes from placentas in Preeclampsia.

IF 1.5 4区医学 Q3 PERIPHERAL VASCULAR DISEASE Clinical and Experimental Hypertension Pub Date : 2022-10-11 DOI:10.1080/10641963.2022.2130930

Xiufang Wang, Andong He, Ka Cheuk Yip, Xiaoting Liu, Ruiman Li

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Abstract

Introduction: Preeclampsia (PE) is a serious pregnancy syndrome. Advanced maternal age (≥ 35 years old) is one of the major risk factors of PE and placental aging is considered to be related to this disease. However, the mechanisms underlying these phenomena remain obscured.

Methods: Gene expression profiles of PE and non-PE placental samples were curated from the GSE75010 dataset. A diagnostic model was constructed and immune characteristics of PE subtypes were estimated.

Results: A total of 58 aging-related genes, which may be associated with PE, were identified. Among them, LEP and FLT1 may be key aging-related genes. Based on 5 top genes (PIK3CB, FLT1, LEP, PIK3R1, CSNK1E), a diagnostic nomogram for PE was built (AUC = 0.872 in the GSE75010 dataset). Three molecular subtypes were clustered, which had different immune and angiogenesis characteristics.

Conclusion: The present study suggests the potential implications of aging-related genes in diagnosing PE. Diverse immune characteristics may be involved in the placental aging of PE.

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子痫前期胎盘中衰老相关基因的诊断特征和免疫特征。

导言子痫前期（PE）是一种严重的妊娠综合征。高龄产妇（≥ 35 岁）是子痫前期的主要风险因素之一，胎盘老化也被认为与子痫前期有关。然而，这些现象背后的机制仍不清楚：方法：从 GSE75010 数据集中收集 PE 和非 PE 胎盘样本的基因表达谱。结果：共发现 58 个与衰老相关的基因：结果：共鉴定出 58 个可能与 PE 相关的衰老相关基因。结果：共发现 58 个可能与 PE 相关的衰老相关基因，其中 LEP 和 FLT1 可能是关键的衰老相关基因。基于 5 个顶级基因（PIK3CB、FLT1、LEP、PIK3R1、CSNK1E），建立了 PE 的诊断提名图（GSE75010 数据集中的 AUC = 0.872）。三个分子亚型被聚类，它们具有不同的免疫和血管生成特征：本研究提示了衰老相关基因在诊断 PE 中的潜在意义。结论：本研究提示了衰老相关基因在诊断 PE 中的潜在意义，不同的免疫特征可能参与了 PE 的胎盘衰老。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Hypertension 医学-外周血管病

CiteScore

3.90

自引率

0.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical and Experimental Hypertension is a reputable journal that has converted to a full Open Access format starting from Volume 45 in 2023. While previous volumes are still accessible through a Pay to Read model, the journal now provides free and open access to its content. It serves as an international platform for the exchange of up-to-date scientific and clinical information concerning both human and animal hypertension. The journal publishes a wide range of articles, including full research papers, solicited and unsolicited reviews, and commentaries. Through these publications, the journal aims to enhance current understanding and support the timely detection, management, control, and prevention of hypertension-related conditions. One notable aspect of Clinical and Experimental Hypertension is its coverage of special issues that focus on the proceedings of symposia dedicated to hypertension research. This feature allows researchers and clinicians to delve deeper into the latest advancements in this field. The journal is abstracted and indexed in several renowned databases, including Pharmacoeconomics and Outcomes News (Online), Reactions Weekly (Online), CABI, EBSCOhost, Elsevier BV, International Atomic Energy Agency, and the National Library of Medicine, among others. These affiliations ensure that the journal's content receives broad visibility and facilitates its discoverability by professionals and researchers in related disciplines.