Cerium oxide nanoparticles modulate liver X receptor and short heterodimer partner, and attenuate liver steatosis and steatohepatitis in a rat model of postmenopausal obesity.

IF 1.3 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY General physiology and biophysics Pub Date : 2022-09-01 DOI:10.4149/gpb_202235

Fatma M Lebda, Sahar M El Agaty, Radwa H Ali, Ghada Galal Hamam, Aliaa M Abd El-Monem, Noha N Lasheen

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引用次数: 1

Abstract

This study aimed to investigate the effect of cerium oxide nanoparticles (CeO2-NPs) on non-alcoholic fatty liver disease in postmenopausal obesity and the underlying mechanisms.64 adult female rats were allocated into Sham, ovariectomized (OVX), high-fat high-fructose dietfed- OVX (HFHF-OVX), and HFHF-OVX-CeO2-NPs-treated (CeO2-HFHF-OVX) groups. OVX and HFHF-OVX rats presented a significant increase in overall and visceral obesity, dyslipidemia, liver enzymes, serum malondialdehyde, liver TNF-α, TGF-β1 and free fatty acids, liver X receptor (LXR) expression associated with decreased serum total antioxidant capacity and liver short heterodimer partner (SHP) expression vs. Sham group. Also, histomorphometric studies displayed a significant higher scores of liver steatosis, inflammation and fibrosis. All these parameters were significantly improved by CeO2-NPs treatment in CeO2-HFHF-OVX vs. HFHF-OVX rats. Thus, CeO2-NPs treatment ameliorates liver steatosis, steatohepatitis, and fibrosis in postmenopausal obese rats via alleviation of obesity, dyslipidemia, modulating liver genes involved in lipid metabolism (LXR and SHP), decreasing liver lipogenesis besides its antioxidant and anti-inflammatory effects.

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氧化铈纳米颗粒调节肝脏X受体和短异二聚体伴侣，减轻绝经后肥胖大鼠肝脏脂肪变性和脂肪性肝炎。

本研究旨在探讨氧化铈纳米颗粒(CeO2-NPs)对绝经后肥胖患者非酒精性脂肪性肝病的影响及其潜在机制。将64只成年雌性大鼠分为假手术组、去卵巢组(OVX)、高脂高果糖饮食-OVX组(HFHF-OVX)和HFHF-OVX- ceo2 - nps组(CeO2-HFHF-OVX)。与Sham组相比，OVX和HFHF-OVX大鼠整体和内脏肥胖、血脂异常、肝酶、血清丙二醛、肝脏TNF-α、TGF-β1和游离脂肪酸、肝脏X受体(LXR)表达显著增加，血清总抗氧化能力下降，肝脏短异二聚体伴侣(SHP)表达显著增加。此外，组织形态学研究显示肝脏脂肪变性、炎症和纤维化的评分明显较高。CeO2-NPs处理对CeO2-HFHF-OVX大鼠的上述指标均有显著改善。因此，CeO2-NPs治疗通过减轻肥胖、血脂异常、调节参与脂质代谢的肝脏基因(LXR和SHP)、减少肝脏脂肪生成以及抗氧化和抗炎作用，改善绝经后肥胖大鼠的肝脏脂肪变性、脂肪性肝炎和纤维化。

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来源期刊

General physiology and biophysics 生物-生化与分子生物学

CiteScore

2.70

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： General Physiology and Biophysics is devoted to the publication of original research papers concerned with general physiology, biophysics and biochemistry at the cellular and molecular level and is published quarterly by the Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences.