Reasons for hospitalization and in-hospital mortality in adults with systemic sclerosis: Analysis of the National Inpatient Sample.

IF 1.4 Q3 RHEUMATOLOGY Journal of Scleroderma and Related Disorders Pub Date : 2022-10-01 Epub Date: 2022-05-11 DOI:10.1177/23971983221083225
Joanna Potera, Augustine M Manadan
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Abstract

Objective: Systemic sclerosis is an autoimmune condition with significant morbidity and mortality despite modern medical therapies. The goal of this investigation was to comprehensively analyze all reasons for hospitalization and in-hospital death of systemic sclerosis patients.

Methods: We conducted a retrospective analysis of the adult systemic sclerosis hospitalizations from the 2016-2018 National Inpatient Sample. We included patients with a primary or secondary diagnosis of systemic sclerosis and compared them to the group without the disease. The incidence of inpatient death and total hospitalization charges were recorded along with the most frequent principal diagnoses for systemic sclerosis hospitalizations and mortality categorized into subgroups.

Results: There were 94,515 adult systemic sclerosis hospitalizations recorded in the 2016-2018 National Inpatient Sample database. Systemic sclerosis patients had higher inpatient mortality compared to the non-systemic sclerosis group (4.5% vs 2.2%, respectively, p < 0.0001), were more likely to be female (84% vs 58%, p < 0.0001), had a longer mean length of stay (6.1 vs 4.7 days, p < 0.0001), and greater mean total hospital charges ($70,018 vs $53,556, p < 0.0001). Sepsis, unspecified organism (A41.9) was the most common principal diagnosis for both hospitalized and deceased systemic sclerosis patients. Cardiovascular diagnoses (21.9%) were the most common reasons for hospitalization and infectious (28%)-for in-hospital death.

Conclusion: Our analysis of the National Inpatient Sample database from 2016 to 2018 showed that infections and cardiovascular diseases were a significant cause of morbidity and mortality among hospitalized systemic sclerosis patients. Sepsis was the most frequent specific diagnosis for both hospitalization and inpatient deaths. These results stress the importance of early recognition of life-threatening infections in this patient population.

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成人系统性硬化症患者住院和住院死亡率的原因:全国住院患者样本分析。
目的:系统性硬化症是一种自身免疫性疾病,尽管有现代医学治疗,但其发病率和死亡率都很高。本研究的目的是全面分析系统性硬化症患者住院和住院死亡的所有原因。方法:我们对2016-2018年全国住院患者样本中的成人系统性硬化症住院患者进行了回顾性分析。我们纳入了一级或二级诊断为系统性硬化症的患者,并将他们与没有该疾病的组进行了比较。记录住院死亡的发生率和总住院费用,以及系统性硬化症住院最常见的主要诊断和分类为亚组的死亡率。结果:2016-2018年全国住院患者样本数据库中记录的成人系统性硬化症住院人数为94515人。与非系统性硬化组相比,系统性硬化患者的住院死亡率更高(分别为4.5%和2.2%,p 结论:我们对2016年至2018年全国住院患者样本数据库的分析表明,感染和心血管疾病是住院系统性硬化症患者发病率和死亡率的重要原因。败血症是住院和住院死亡中最常见的特异性诊断。这些结果强调了早期识别该患者群体中危及生命的感染的重要性。
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来源期刊
CiteScore
4.10
自引率
0.00%
发文量
31
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