Comparison of Hemodynamic Changes in Patients Undergoing Laparoscopic Cholecystectomy using rocuronium and vecuronium for Intubation and Maintenance under General Anesthesia.

Abstract

Context: The context of the study is to compare and find better muscle relaxant between rocuronium and vecuronium for intubation and maintenance under general anesthesia in patients undergoing laparoscopic cholecystectomy.

Aims: The aim of the study is to measure intubating condition, hemodynamic changes during intubation and also during maintenance of general anesthesia and to record complications, if any.

Settings and design: A prospective clinical study conducted in the Department of Anesthesiology in tertiary care center.

Materials and methods: A total of 100 patients of the American Society of Anesthesiologists Classes Grade I and II were planned for laparoscopic cholecystectomy were divided into two groups of 50 each. The subjects in the control and study group were put under anesthesia using injection propofol 2.0 mg.kg^-1 along with injection vecuronium 0.10 mg.kg^-1 and injection propofol 2.0 mg.kg^-1 along with injection rocuronium 0.60 mg.kg^-1, respectively. Hemodynamic monitoring and oxygen saturation (SPO₂) were recorded at various intervals.

Statistical analysis used: All the collected data were imported into Microsoft Excel, and the statistical analysis was done by using SPSS 25.0 version.

Results: The mean heart rate before and after carboperitoneum at different time intervals and before and after extubation was significantly lower in vecuronium group. The mean systolic blood pressure and mean arterial pressure at 1 and 5 minutes after extubation were significantly more among vecuronium group.

Conclusions: Rocuronium is reasonably cardiostable, produces excellent intubation conditions, has a shorter duration of action, and shows minimal cumulative effect.