Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature.

Case Reports in Rheumatology Pub Date : 2022-09-20 eCollection Date: 2022-01-01 DOI:10.1155/2022/1233522

Syoko Tsubouchi, Takahiro Mizuuchi, Yusuke Yamamoto, Daiki Fujimori, Kayo Ishii, Mayu Tago, Eri Kato, Hiroaki Mori, Haeru Hayashi, Koichiro Tahara, Tetsuji Sawada

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Abstract

Renal involvement is underestimated as an extramuscular manifestation of dermatomyositis (DM). Here, we describe a 67-year-old woman with anti-glycyl-transfer ribonucleic acid synthetase (anti-EJ) antibody and anti-ribonucleoprotein antibody-positive DM complicated by systemic sclerosis, who developed nephrotic syndrome concurrently with the exacerbation of DM, as indicated by incremental serum creatine kinase levels, high-intensity lesions on muscle magnetic resonance imaging, and active interstitial pneumonitis on chest computed tomography. Renal biopsy revealed the presence of immune-deposition in the glomerulus by immunofluorescence. To our knowledge, this is the first report describing the coexistence of anti-EJ antibody-positive DM and nephrotic syndrome. More reports of similar cases are warranted to substantiate the association.

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肾病综合征作为抗ej抗体阳性皮肌炎的肌外表现:1例报告及文献复习。

肾脏受累被低估为皮肌炎(DM)的肌肉外表现。在这里，我们描述了一位67岁的女性，她患有抗甘氨酸转移核糖核酸合成酶(抗ej)抗体和抗核糖核蛋白抗体阳性的糖尿病合并系统性硬化症，她在糖尿病加重的同时出现了肾病综合征，这可以从血清肌酸激酶水平的增加、肌肉磁共振成像上的高强度病变和胸部计算机断层扫描上的活动性间质性肺炎看出。肾活检显示免疫荧光在肾小球中存在免疫沉积。据我们所知，这是第一个描述抗ej抗体阳性的糖尿病和肾病综合征共存的报告。有更多类似案例的报道可以证实这种联系。

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Case Reports in Rheumatology

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12 weeks