Triglyceride Level- and MTHFR- Specific Mediation Effect of Handgrip Strength on the Association of Dietary Protein Intake and Cognitive Function in the Chinese Elderly.

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY Current Alzheimer research Pub Date : 2022-10-07 DOI:10.2174/1567205019666221007093500

Ling Huang, Qian Liu, Jingzhu Fu, Dezheng Zhou, Yue Sun, Huilian Duan, Tong Yang, Jing Zhao, Zehao Wang, Zhenshu Li, Cuixia Dong, Ning Xu, Qinghan Ren, Guoquan Zhang, Wen Li, Fei Ma, Jing Yan, Yue Du, Huan Liu, Changqing Sun, Guangshun Wang, Guowei Huang, Yongjie Chen

{"title":"Triglyceride Level- and MTHFR- Specific Mediation Effect of Handgrip Strength on the Association of Dietary Protein Intake and Cognitive Function in the Chinese Elderly.","authors":"Ling Huang, Qian Liu, Jingzhu Fu, Dezheng Zhou, Yue Sun, Huilian Duan, Tong Yang, Jing Zhao, Zehao Wang, Zhenshu Li, Cuixia Dong, Ning Xu, Qinghan Ren, Guoquan Zhang, Wen Li, Fei Ma, Jing Yan, Yue Du, Huan Liu, Changqing Sun, Guangshun Wang, Guowei Huang, Yongjie Chen","doi":"10.2174/1567205019666221007093500","DOIUrl":null,"url":null,"abstract":"Background: Recent findings suggest that both dietary protein intake and hand grip strength (HGS) were associated with cognitive function, however, few studies have been devoted specifically to the mediation effect of HGS on the association of dietary protein with cognitive function.Objectives: To confirm the hypothesis that HGS mediated the association of dietary protein intake with cognitive function in the elderly, which was modified by triglyceride level and methylenetetrahydrofolate reductase (MTHFR) gene status.Methods: This cross-sectional study included 3,268 participants. Dietary protein intake, HGS, and cognitive function were collected by food frequency questionnaires (FFQ), grip measurements and mini mental state examination (MMSE), respectively. In this mediation analysis, dietary protein intake was entered as independent variable, HGS was entered as mediator, and cognitive function was entered as dependent variable.Results: HGS significantly mediated the associations of dietary protein (β = 0.0013, 95% CI: 0.0007, 0.0022), animal protein (β = 0.0024, 95% CI: 0.0012, 0.0037), and plant protein intake (β = 0.0011, 95% CI: 0.0001, 0.0023) with cognitive function in total participants, with the mediated proportion of 16.19%, 12.45% and 20.57%, respectively. Furthermore, significant mediation effects of HGS on the associations of dietary protein, animal protein, and plant protein intake with MMSE score were found in the elderly without hypertriglyceridemia or in MTHFR C677T CC/CT carriers.Conclusion: This study suggested that HGS mediated the association of dietary protein intake with cognitive function, and this mediation effect was modified by triglyceride level and MTHFR C677T gene status.","PeriodicalId":10810,"journal":{"name":"Current Alzheimer research","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2022-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Alzheimer research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/1567205019666221007093500","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Recent findings suggest that both dietary protein intake and hand grip strength (HGS) were associated with cognitive function, however, few studies have been devoted specifically to the mediation effect of HGS on the association of dietary protein with cognitive function.

Objectives: To confirm the hypothesis that HGS mediated the association of dietary protein intake with cognitive function in the elderly, which was modified by triglyceride level and methylenetetrahydrofolate reductase (MTHFR) gene status.

Methods: This cross-sectional study included 3,268 participants. Dietary protein intake, HGS, and cognitive function were collected by food frequency questionnaires (FFQ), grip measurements and mini mental state examination (MMSE), respectively. In this mediation analysis, dietary protein intake was entered as independent variable, HGS was entered as mediator, and cognitive function was entered as dependent variable.

Results: HGS significantly mediated the associations of dietary protein (β = 0.0013, 95% CI: 0.0007, 0.0022), animal protein (β = 0.0024, 95% CI: 0.0012, 0.0037), and plant protein intake (β = 0.0011, 95% CI: 0.0001, 0.0023) with cognitive function in total participants, with the mediated proportion of 16.19%, 12.45% and 20.57%, respectively. Furthermore, significant mediation effects of HGS on the associations of dietary protein, animal protein, and plant protein intake with MMSE score were found in the elderly without hypertriglyceridemia or in MTHFR C677T CC/CT carriers.

Conclusion: This study suggested that HGS mediated the association of dietary protein intake with cognitive function, and this mediation effect was modified by triglyceride level and MTHFR C677T gene status.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

手握力对中国老年人膳食蛋白质摄入与认知功能相关性的甘油三酯水平和 MTHFR 特异性中介效应

背景：最近的研究结果表明，膳食蛋白质摄入量和手握力（HGS）都与认知功能有关，但很少有研究专门探讨HGS对膳食蛋白质与认知功能的关联的中介作用：目的：证实 HGS 对膳食蛋白质摄入量与老年人认知功能的相关性具有中介作用，而甘油三酯水平和亚甲基四氢叶酸还原酶（MTHFR）基因状态会改变这种中介作用的假设：这项横断面研究包括 3268 名参与者。通过食物频率问卷（FFQ）、握力测量和迷你精神状态检查（MMSE）分别收集了膳食蛋白质摄入量、HGS和认知功能。在该中介分析中，膳食蛋白质摄入量为自变量，HGS为中介变量，认知功能为因变量：结果：在所有参与者中，HGS对膳食蛋白质（β=0.0013，95% CI：0.0007，0.0022）、动物蛋白质（β=0.0024，95% CI：0.0012，0.0037）和植物蛋白质摄入量（β=0.0011，95% CI：0.0001，0.0023）与认知功能之间的关系有明显的中介作用，中介作用比例分别为16.19%、12.45%和20.57%。此外，在没有高甘油三酯血症的老年人或MTHFR C677T CC/CT携带者中，HGS对膳食蛋白质、动物蛋白和植物蛋白摄入量与MMSE评分的关系有明显的中介作用：本研究表明，HGS能调节膳食蛋白质摄入量与认知功能的关系，而甘油三酯水平和MTHFR C677T基因状态会改变这种调节作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Current Alzheimer research 医学-神经科学

CiteScore

4.00

自引率

4.80%

发文量

审稿时长

4-8 weeks

期刊介绍： Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer''s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ''bird''s-eye view'' of the current state of Alzheimer''s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.