Cytological Analysis of Low-grade Squamous Intraepithelial Lesion with a Histodiagnosis of Cervical Intraepithelial Neoplasia 3 (Severe Dysplasia) Prospectively.

IF 0.1 4区医学 Q4 Medicine Analytical and Quantitative Cytopathology and Histopathology Pub Date : 2015-06-01

Kiyotada Washiya, Chika Saito, Hiroshi Nanjo, Tatsuo Sugiyama, Kazunosuke Abe, Jun Watanabe

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Abstract

Objective: To reanalyze the cytological features of the first cytological specimens of cervical intraepithelial neoplasia 3 (CIN3) (severe) cases that were initially cytodiagnosed as LSIL and followed up for up to 5 years.

Study design: Among 14,556.patients in 2009, 236 (1.6%) were cytodiagnosed with low-grade squamous intraepithelial lesion (LSIL). Among those, 128 cases could be histologically diagnosed from 2009 to 2013. Among those 128 cases, 16 were diagnosed as CIN3 (severe). The first cytological specimens of those 16 cases were reanalyzed morphologically.

Results: The first cytological specimens of the 16 cases diagnosed as LSIL and histodiagnosed as CIN3 (severe) showed a few small atypical cells in 13 and a cluster of small atypical cells in 1 case. Atypical cells indicating CIN1 were predominant in 14 LSIL cases and there were a few small atypical cells in these cases (LSIL, cannot exclude high-grade squamous intraepithelial lesion [LSIL-H]).

Conclusion: We show the existence of LSIL-H (LSIL, cannot exclude HSIL) cases, for which biopsy with colposcopy should be applied actively.

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低级别鳞状上皮内病变伴宫颈上皮内瘤变3(严重不典型增生)的细胞学分析。

目的:重新分析宫颈上皮内瘤变3 (CIN3)(严重)病例首次细胞学标本的细胞学特征，这些病例最初被细胞诊断为LSIL，并随访长达5年。研究设计:14556人。2009年，236例(1.6%)患者被细胞诊断为低级别鳞状上皮内病变(LSIL)。其中2009 - 2013年组织学诊断128例。128例中16例诊断为CIN3(严重)。对16例患者的首次细胞学标本进行形态学分析。结果:16例诊断为LSIL，组织诊断为CIN3(重度)的患者，首次细胞学检查13例显示少量小非典型细胞，1例显示一簇小非典型细胞。14例低级别鳞状上皮内病变以非典型细胞(CIN1)为主，少数小的非典型细胞(LSIL，不能排除高级别鳞状上皮内病变[LSIL- h])。结论:我们认为存在LSIL- h (LSIL，不能排除HSIL)病例，应积极应用阴道镜活检。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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