O V Payushina, N N Butorina, O N Sheveleva, E I Domaratskaya
{"title":"[Comparative Analysis of Subpopulations of Mesenchymal Stromal Cells of the Bone Marrow and Fetal Liver Differing in Sensitivity to 5-Fluorouracil].","authors":"O V Payushina, N N Butorina, O N Sheveleva, E I Domaratskaya","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>It is shown that the effect of 5-fluorouracil (5-FU) on mesenchymal stromal cells (MSCs) of the bone marrow and fetal liver of the rat increases the population of cells with a reduced proliferative potential. It is shown that, in the course of passaging, the 5-FU-resistant MSCs of the bone marrow and fetal liver lose their ability to differentiate in the osteogenic direction more and less rapidly, respectively, than the 5-FU-sensitive MSCs.</p>","PeriodicalId":77187,"journal":{"name":"Izvestiia Akademii nauk. Seriia biologicheskaia","volume":" ","pages":"258-64"},"PeriodicalIF":0.0000,"publicationDate":"2015-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Izvestiia Akademii nauk. Seriia biologicheskaia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
It is shown that the effect of 5-fluorouracil (5-FU) on mesenchymal stromal cells (MSCs) of the bone marrow and fetal liver of the rat increases the population of cells with a reduced proliferative potential. It is shown that, in the course of passaging, the 5-FU-resistant MSCs of the bone marrow and fetal liver lose their ability to differentiate in the osteogenic direction more and less rapidly, respectively, than the 5-FU-sensitive MSCs.