Prostasin: An Epithelial Sodium Channel Regulator.

Journal of biomarkers Pub Date : 2013-01-01 Epub Date: 2013-07-02 DOI:10.1155/2013/179864
Shakti Aggarwal, Pradeep K Dabla, Sarika Arora
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引用次数: 14

Abstract

Prostasin is a glycophosphatidylinositol-anchored protein which is found in prostate gland, kidney, bronchi, colon, liver, lung, pancreas, and salivary glands. It is a serine protease with trypsin-like substrate specificity which was first purified from seminal fluid in 1994. In the last decade, its diverse roles in various biological and physiological processes have been elucidated. Many studies done to date suggest that prostasin is one of several membrane peptidases regulating epithelial sodium channels in mammals. A comprehensive literature search was conducted from the websites of Pubmed Central, the US National Library of Medicine's digital archive of life sciences literature and the National Library of Medicine. The data was also assessed from journals and books that published relevant articles in this field. Understanding the mechanism by which prostasin and its inhibitors regulate sodium channels has provided a new insight into the treatment of hypertension and some other diseases like cystic fibrosis. Prostasin plays an important role in epidermal growth factor receptor (EGFR) signal modulation. Extracellular proteases have been implicated in tumor metastasis and local tissue invasion because of their ability to degrade extracellular matrices.

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前列腺素:上皮钠通道调节剂。
前列腺蛋白酶是一种糖磷脂酰肌醇锚定蛋白,存在于前列腺、肾脏、支气管、结肠、肝脏、肺、胰腺和唾液腺中。它是一种丝氨酸蛋白酶,具有胰蛋白酶样底物特异性,于1994年首次从精液中纯化。在过去的十年中,它在各种生物和生理过程中的不同作用已经被阐明。迄今为止的许多研究表明,前列腺蛋白酶是调节哺乳动物上皮钠通道的几种膜肽酶之一。从Pubmed Central网站、美国国家医学图书馆生命科学文献数字档案和国家医学图书馆进行了全面的文献检索。数据还从发表该领域相关文章的期刊和书籍中进行了评估。了解前列腺素及其抑制剂调节钠通道的机制为高血压和其他一些疾病(如囊性纤维化)的治疗提供了新的见解。前列腺蛋白酶在表皮生长因子受体(EGFR)信号调节中起重要作用。细胞外蛋白酶由于其降解细胞外基质的能力而与肿瘤转移和局部组织侵袭有关。
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