Evaluation of Motor Neuron Excitability by CMAP Scanning with Electric Modulated Current.

Neuroscience journal Pub Date : 2015-01-01 Epub Date: 2015-08-26 DOI:10.1155/2015/360648

Tiago Araújo, Rui Candeias, Neuza Nunes, Hugo Gamboa

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引用次数: 4

Abstract

Introduction. Compound Muscle Action Potential (CMAP) scan is a noninvasive promissory technique for neurodegenerative pathologies diagnosis. In this work new CMAP scan protocols were implemented to study the influence of electrical pulse waveform on peripheral nerve excitability. Methods. A total of 13 healthy subjects were tested. Stimulation was performed with an increasing intensities range from 4 to 30 mA. The procedure was repeated 4 times per subject, using a different single pulse stimulation waveform: monophasic square and triangular and quadratic and biphasic square. Results. Different waveforms elicit different intensity-response amplitude curves. The square pulse needs less current to generate the same response amplitude regarding the other waves and this effect is gradually decreasing for the triangular, quadratic, and biphasic pulse, respectively. Conclusion. The stimulation waveform has a direct influence on the stimulus-response slope and consequently on the motoneurons excitability. This can be a new prognostic parameter for neurodegenerative disorders.

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调制电流CMAP扫描对运动神经元兴奋性的评价。

介绍。复合肌动作电位(CMAP)扫描是一种无创的神经退行性病理诊断技术。本文采用新的CMAP扫描方案来研究电脉冲波形对周围神经兴奋性的影响。方法。共对13名健康受试者进行了测试。刺激强度从4到30 mA不等。每个受试者重复4次，使用不同的单脉冲刺激波形:单相方形、三角形、二次和双相方形。结果。不同的波形产生不同的强度-响应振幅曲线。对于其他波，方形脉冲产生相同的响应幅值所需的电流更少，而对于三角形脉冲、二次脉冲和双相脉冲，这种影响分别逐渐减小。结论。刺激波形直接影响刺激-反应斜率，从而影响运动神经元的兴奋性。这可能是神经退行性疾病的一个新的预后参数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Neuroscience journal

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