Chronic fatigue syndrome.

BMJ clinical evidence Pub Date : 2015-09-28

Anthony J Cleare, Steven Reid, Trudie Chalder, Matthew Hotopf, Simon Wessely

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Abstract

Introduction: Chronic fatigue syndrome affects between 0.006% and 3% of the population depending on the criteria of definition used, with women being at higher risk than men.

Methods and outcomes: We conducted a systematic overview, aiming to answer the following clinical question: What are the effects of selected treatments for chronic fatigue syndrome? We searched: Medline, Embase, The Cochrane Library, and other important databases up to November 2013 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review).

Results: At this update, searching of electronic databases retrieved 169 studies. After deduplication and removal of conference abstracts, 86 records were screened for inclusion in the overview. Appraisal of titles and abstracts led to the exclusion of 71 studies and the further review of 15 full publications. Of the 15 full articles evaluated, two systematic reviews, one RCT, and one further follow-up report of an RCT were added at this update. We performed a GRADE evaluation for 23 PICO combinations.

Conclusions: In this systematic overview, we categorised the effectiveness of four interventions based on information relating to the effectiveness and safety of antidepressants, cognitive behavioural therapy, corticosteroids, and graded exercise therapy.

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慢性疲劳综合症。

根据使用的定义标准，慢性疲劳综合征影响0.006%至3%的人口，女性的风险高于男性。方法和结果:我们进行了系统的综述，旨在回答以下临床问题:选择治疗慢性疲劳综合征的效果如何?我们检索了截至2013年11月的Medline、Embase、The Cochrane Library和其他重要数据库(临床证据综述定期更新;请查看我们的网站获取最新版本的评论)。结果:在本次更新中，检索电子数据库检索到169项研究。在删除和删除会议摘要后，86条记录被筛选纳入概述。对标题和摘要的评估导致71项研究被排除，并进一步审查了15份完整的出版物。在评估的15篇全文中，在本次更新中增加了两篇系统评价、一项随机对照试验和一项随机对照试验的进一步随访报告。我们对23个PICO组合进行了GRADE评估。结论:在这篇系统综述中，我们根据抗抑郁药、认知行为疗法、皮质类固醇和分级运动疗法的有效性和安全性信息对四种干预措施的有效性进行了分类。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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