CXCL12 and CXCR4 as predictive biomarkers of glioma recurrence pattern after total resection

Pathologie-biologie Pub Date : 2015-09-01 DOI:10.1016/j.patbio.2015.07.002

W. Tang , X. Wang , Y. Chen , J. Zhang , Y. Chen , Z. Lin

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引用次数: 20

Abstract

Purpose of the study

Previous studies have shown that the pattern of recurrence for glioma is related to the direction of glioma cell invasion. Recent studies demonstrated that the CXCL12/CXCR4 signaling pathway mediates cellular invasion in glioma. Therefore, in this study, we investigated the possible relationship between CXCL12/CXCR4 expression and recurrence pattern in glioma.

Patients and methods

Immunohistochemical techniques were used to assess CXCL12/CXCR4 expression in 42 glioma tissues following total resection. According to magnetic resonance imaging (MRI) of gliomas, the recurrence pattern was classified as close or distant pattern. The relationship between recurrence pattern and CXCL12/CXCR4 expression were initially examined by Chi-squared analysis. The prognostic significance of CXCL12 and CXCR4 was determined by log-rank tests and COX proportional hazards model.

Results

CXCL12 was expressed mainly in vascular endothelial cells and CXCR4 was expressed mainly in tumor cells. The recurrence pattern was significantly related to the expression level of CXCL12 in vascular endothelial cells (P = 0.002) and CXCR4 in tumor cells (P = 0.004). However, CXCL12 and CXCR4 were not independent prognostic factors for progression-free survival or overall survival in glioma patients.

Conclusion

The glioma recurrence pattern is related to CXCL12 expression levels in vascular endothelial cells and CXCR4 expression levels in tumor cells; thus, implicating the CXCL12/CXCR4 signaling pathway as a potential target for glioma therapy.

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CXCL12和CXCR4作为胶质瘤全切除后复发模式的预测性生物标志物

研究目的既往研究表明胶质瘤的复发方式与胶质瘤细胞侵袭方向有关。最近的研究表明，CXCL12/CXCR4信号通路介导胶质瘤的细胞侵袭。因此，在本研究中，我们探讨了CXCL12/CXCR4表达与胶质瘤复发模式之间的可能关系。采用免疫组化技术评估42例胶质瘤全切除术后组织中CXCL12/CXCR4的表达。根据脑胶质瘤的磁共振成像(MRI)，复发类型分为近端复发和远端复发。复发方式与CXCL12/CXCR4表达的关系初步采用卡方分析。通过log-rank检验和COX比例风险模型确定CXCL12和CXCR4的预后意义。结果scxcl12主要在血管内皮细胞中表达，CXCR4主要在肿瘤细胞中表达。复发方式与血管内皮细胞中CXCL12表达水平(P = 0.002)和肿瘤细胞中CXCR4表达水平(P = 0.004)相关。然而，CXCL12和CXCR4并不是胶质瘤患者无进展生存期或总生存期的独立预后因素。结论胶质瘤复发模式与血管内皮细胞中CXCL12表达水平和肿瘤细胞中CXCR4表达水平有关;因此，暗示CXCL12/CXCR4信号通路是神经胶质瘤治疗的潜在靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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