Evaluation of the Role of Granzyme B in Exuberant Scar Pathogenesis: An Immunohistochemical Study.

IF 0.1 4区医学 Q4 Medicine Analytical and Quantitative Cytopathology and Histopathology Pub Date : 2015-08-01

Ola Ahmed Bakry, Shereen Fouad Younes, Moshira Abdel Wahed, Shawky Mahmoud El Farargy, Shaimaa Sharawy

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Abstract

Objective: To evaluate the possible role of Granzyme B (GzmB) in abnormal wound healing through its immunohistochemical expression in keloid and hypertrophic scars and to study the relationship of its expression with the clinicopathologic parameters of studied cases.

Study design: Using immunohistochemical techniques, GzmB was analyzed in skin biopsies of 44 patients (30 cases with abnormal scars [21 with keloid and 9 with hypertrophic scars] and 14 age- and gender-matched cases with surgical scars as a control group).

Results: GzmB was expressed in keratinocytes in 28.6%, 66.7%, and 23.8% of surgical scars, hypertrophic scars, and keloids, respectively. Dermal expression in inflammatory cells was detected in 64.3%, 44.4%, and 28.6% of surgical scars, hypertrophic scars, and keloids, respectively. No significant difference was noted in GzmB expression intensity or percent in comparison between studied groups.

Conclusion: GzmB plays no role in the pathogenesis of keloids and hypertrophic scars. Further large-scaled studies are needed to expand or refute the current observation.

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评价颗粒酶B在增生性瘢痕发病机制中的作用:免疫组织化学研究。

目的:探讨颗粒酶B (Granzyme B, GzmB)在瘢痕疙瘩和增生性瘢痕中的免疫组化表达在伤口异常愈合中的可能作用，并探讨其表达与所研究病例的临床病理参数的关系。研究设计:采用免疫组化技术，对44例皮肤活检患者(30例疤痕异常[21例瘢痕瘤，9例增生性疤痕]，14例年龄和性别匹配的手术疤痕患者作为对照组)进行GzmB分析。结果:GzmB在手术瘢痕、增生性瘢痕和瘢痕疙瘩的角质形成细胞中表达分别为28.6%、66.7%和23.8%。在手术疤痕、增生性疤痕和瘢痕疙瘩中分别有64.3%、44.4%和28.6%的皮肤组织检测到炎症细胞的表达。GzmB的表达强度和百分比在两组间无显著差异。结论:GzmB在瘢痕疙瘩和增生性瘢痕的发病机制中无作用。需要进一步的大规模研究来扩展或反驳目前的观察结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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