[A CLINICAL EXPERIENCE OF RIFAMPICIN SUPPOSITORY FOR THE TREATMENT OF PULMONARY TUBERCULOSIS].

Abstract

Purpose: The usefulness of a rifampicin (RFP) suppository for treatment of pulmonary tuberculosis was examined in patients who had difficulty with oral consumption of medication.

Subjects and methods: Among inpatients receiving first-time treatment for pulmonary tuberculosis susceptible to both isoniazid (INH) and RFP, and who underwent standard 3- or 4-drug treatments including INH and RFP, we compared the number of days required for obtaining two and three consecutive negative sputum smears and cultures, respectively, in patients who received hospital-made suppositories or standard oral RFP administration.

Results: There was no significant difference between groups in the number of days required for negative cultures and smears; although the times were equivalent, there were more number of elderly patients and those in generally poor condition in the RFP suppository group than the oral intake group.

Conclusion: RFP suppositories may be one method for administration of standard tuberculosis treatment in patients with difficulty in oral consumption of medication.