[Solid phase peptide synthesis: interest in the valorization of molecular substances from animal venoms].

Abstract

Toxins from animal venoms are small peptide molecules able to interact with a wide range of specific cellular targets in order to modulate their activity, which enables them to act in many physiological and pathological processes. Recently, structuralandpharmacologicalstudieshaveshown the involvement of these biological agents in the pathogenesis of many diseases like diabetes, cancer paralysis, autoimmune diseases or neurological disorders. Nevertheless, the only punfication from scorpion venoms of theses peptides still doesn't offer sufficient quantities to allow conducting the pharmacological and structure-function studies. The solid phases peptide synthesis (SPPS) is a methodology that allows us to produce non-limited quantities of structural analogsfrom these peptides-toxins in. In this paper; we will try to highlight the importance of this methodology, and peptide engineering in general, in obtaining peptides of interest. We are also going to elucidate the problems encountered during the chemical synthesis of some betides and explain how to overcome them.