[PREIMPLANTATION DEVELOPMENT OF HUMAN EMBRYOS WITH NUMERICAL CHROMOSOME ABNORMALITIES IN VITRO].

TSitologiia i genetika Pub Date : 2015-07-01
O V Chaplia, J V Gontar, N M Bilko
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Abstract

The study was focused on morphokynetic characteristics of in vitro cultured human embryos that were considered to be aneuploid or euploid according to the preimplantation genetic screening results. Among all the embryos examined only 34.2% were chromosomally balanced, while others possessed isolated or combined chromosome abnormalities. Although morphological features of cleaving pathologic and euploid embryos did not differ significantly, on the fifth day of culture chromosomally balanced specimen formed "expanded" blastocyst twice as frequently as abnormal ones. Moreover, development of 38.4% of aneuploid embryos was compromised before the initiation of cavitation. Thus, prolonged embryo culture advances selection of samples with the highest implantation potential for the transfer on the basis of the morphokynetic characteristics and helps to avoid additional genetic testing.

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[体外数字染色体异常人类胚胎的着床前发育]。
研究着床前遗传筛选结果认为非整倍体或整倍体体外培养人胚胎的形态动力学特征。在所有被检查的胚胎中,只有34.2%的胚胎染色体平衡,而其他胚胎则具有单独或合并的染色体异常。虽然病理胚和整倍体胚的形态特征没有明显差异,但在培养第5天,染色体平衡的标本形成“膨大”囊胚的频率是异常囊胚的两倍。此外,38.4%的非整倍体胚胎在空化开始前发育受损。因此,延长胚胎培养有助于在形态动力学特征的基础上选择具有最高植入潜力的样本进行移植,并有助于避免额外的基因检测。
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