Synthesis of Some Benzimidazole Derivatives Bearing 1,3,4-Oxadiazole Moiety as Anticancer Agents.

Bereket Mochona, Elizabeth Mazzio, Madhavei Gangapurum, Nelly Mateeva, K K Redda
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引用次数: 12

Abstract

In an effort to establish new benzimidazole related structural leads with improved anticancer activity, several new benzimidazole derivatives (5a-i) with 1,3,4-oxadiazole scaffold incorporated were synthesized and studied for their anticancer activity. The anticancer screening against MDA-MB-231 breast cancer cell lines showed that compound (5c) exhibited moderate cytotoxicity.

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含1,3,4-恶二唑基团苯并咪唑类抗癌药物的合成。
为了建立新的具有抗癌活性的苯并咪唑相关结构先导物,合成了几种新的含1,3,4-恶二唑支架的苯并咪唑衍生物(5a-i),并对其抗癌活性进行了研究。对MDA-MB-231乳腺癌细胞株的抗癌筛选表明,化合物(5c)具有中等的细胞毒性。
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