Bereket Mochona, Elizabeth Mazzio, Madhavei Gangapurum, Nelly Mateeva, K K Redda
{"title":"Synthesis of Some Benzimidazole Derivatives Bearing 1,3,4-Oxadiazole Moiety as Anticancer Agents.","authors":"Bereket Mochona, Elizabeth Mazzio, Madhavei Gangapurum, Nelly Mateeva, K K Redda","doi":"10.7598/cst2015.1029","DOIUrl":null,"url":null,"abstract":"<p><p>In an effort to establish new benzimidazole related structural leads with improved anticancer activity, several new benzimidazole derivatives (<b>5a-i</b>) with 1,3,4-oxadiazole scaffold incorporated were synthesized and studied for their anticancer activity. The anticancer screening against MDA-MB-231 breast cancer cell lines showed that compound (<b>5c</b>) exhibited moderate cytotoxicity.</p>","PeriodicalId":10087,"journal":{"name":"Chemical science transactions","volume":"4 2","pages":"534-540"},"PeriodicalIF":0.0000,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594831/pdf/nihms702132.pdf","citationCount":"12","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical science transactions","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7598/cst2015.1029","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 12
Abstract
In an effort to establish new benzimidazole related structural leads with improved anticancer activity, several new benzimidazole derivatives (5a-i) with 1,3,4-oxadiazole scaffold incorporated were synthesized and studied for their anticancer activity. The anticancer screening against MDA-MB-231 breast cancer cell lines showed that compound (5c) exhibited moderate cytotoxicity.