[MORPHOLOGICAL CHANGES IN THE STRIATED MUSCLES AFTER ALBENDAZOLE TREATMENT FOR EXPERIMENTAL TRICHINOSIS].

V I Pustovoit, E Ya Adoeva, S S Kozlov, V S Turitsin, A F Nikitin
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Abstract

Trichinosis was experimentally induced in rats. The morphology of encystation of Trichinella larvae was studied in the striated muscles. The efficacy of albendazole was evaluated in different intensity of Trichinella larvae infestation in the striated muscles of the laboratory animals. Encystation was shown to cease at 21 days. Albendazole showed high activity against intestinal and encapsulated larvae of Trichinella, leading to 100% death of T. spiralis. Capsules and Trichinella larvae were described to be destructed after treatment with albendazole 15 mg/kg twice daily for 10 days.

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[阿苯达唑治疗实验性旋毛虫病后横纹肌的形态学改变]。
用实验方法诱导大鼠旋毛虫病。研究了旋毛虫幼虫在横纹肌内的成囊形态。评价了阿苯达唑对实验动物横纹肌中不同强度旋毛虫幼虫侵染的效果。在21天内,尿路停止。阿苯达唑对旋毛虫肠道和荚膜幼虫有较高的杀灭活性,可使旋毛虫100%死亡。阿苯达唑15 mg/kg每日2次,连续10 d后,旋毛虫胶囊和幼虫均被破坏。
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