[EFFECT OF LIQUID PROBIOTICS ON THE GROWTH OF MYCOBACTERIUM TUBERCULOSIS IN VITRO].

Abstract

The Mycobacterium tuberculosis (MBT) culture isolated from the sputum of 25 patients was experimentally studied. The probiotics were tested for their bacterium-neutralizing effect on a dense Luwenstein-Jensen medium, by using the absolute concentration method. The nature of their bactericidal and bacteriostatic effects was assessed from the presence and intensity of MBT growth on day 21 after inoculation. In most cases, the probiotics exerted an inhibitory effect on MBT growth. The latter was completely or partially suppressed by Trilact in 96% of cases (baseline concentration) and in 80% (1:40 dilution), Bifidum 791 BAG in 92% (baseline concentration) and 84% (1:40 dilution), Biovestin in 76% (baseline concentration) and in 88% (1: 40 dilution), and Biovestin-lacto in 88% (baseline concentration and 1: 40 dilution). Thus, the liquid probiotics have a target antagonistic effect on Mycobacterium tuberculosis growth in vitro, which opens up possibilities for their further study in an effort to use these agents in the complex tuberculosis therapy aimed at enhancing the efficiency of its treatment.