Relationship of Inflammatory Biomarkers with Severity of Peripheral Arterial Disease.

IF 2.5 Q2 PERIPHERAL VASCULAR DISEASE International Journal of Vascular Medicine Pub Date : 2016-01-01 Epub Date: 2016-07-31 DOI:10.1155/2016/6015701
Kimihiro Igari, Toshifumi Kudo, Takahiro Toyofuku, Yoshinori Inoue
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引用次数: 13

Abstract

Objective. The pentraxin family, including high-sensitivity C-reactive protein (hs-CRP), serum amyloid P (SAP), and pentraxin 3 (PTX3), has been identified as playing a key role in inflammatory reactions such as in atherosclerosis and cardiovascular disease. In this study, we examined the relationship between peripheral arterial disease (PAD) and serum levels of pentraxins. Methods. This study was undertaken via a retrospective review of PAD patients with surgical intervention for lesions of the common femoral artery. We evaluated the preoperative patient conditions, hemodynamic status, such as ankle brachial index (ABI), and clinical ischemic conditions according to Rutherford classification. Preoperatively, we collected blood samples for determining the serum levels of hs-CRP, SAP, and PTX3. Results. Twelve PAD patients with common femoral arterial lesions were treated and examined. The hemodynamic severity of PAD was not negatively correlated with hs-CRP, SAP, or PTX3. The clinical severity evaluated by Rutherford classification was significantly positively correlated with the serum level of PTX3 (p = 0.019). Conclusion. We demonstrated that PTX3 might be a better marker of PAD than hs-CRP and SAP. Furthermore, PTX3 might be a prognostic marker to evaluate the severity of PAD.

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炎症生物标志物与外周动脉疾病严重程度的关系。
目标。戊曲霉素家族,包括高敏c反应蛋白(hs-CRP)、血清淀粉样蛋白P (SAP)和戊曲霉素3 (PTX3),已被确定在动脉粥样硬化和心血管疾病等炎症反应中起关键作用。在这项研究中,我们研究了外周动脉疾病(PAD)与戊曲霉素血清水平之间的关系。方法。本研究是通过对因股总动脉病变而接受手术干预的PAD患者进行回顾性研究。我们根据卢瑟福分类评估患者术前状况、血流动力学状态,如踝肱指数(ABI)和临床缺血状况。术前,我们采集血样,测定血清hs-CRP、SAP和PTX3水平。结果。对12例伴有股总动脉病变的PAD患者进行了治疗和检查。PAD血流动力学严重程度与hs-CRP、SAP或PTX3均无负相关。卢瑟福分级评价的临床严重程度与血清PTX3水平呈显著正相关(p = 0.019)。结论。我们证明PTX3可能是比hs-CRP和SAP更好的PAD标志物。此外,PTX3可能是评估PAD严重程度的预后标志物。
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来源期刊
International Journal of Vascular Medicine
International Journal of Vascular Medicine PERIPHERAL VASCULAR DISEASE-
CiteScore
3.50
自引率
0.00%
发文量
7
审稿时长
16 weeks
期刊最新文献
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