[THE EFFECTIVENESS OF DIAGNOSIS AND TREATMENT OF CEREBROVASCULAR DISORDERS IN HYPERTENSIVE ENCEPHALOPATHY IN ELDERLY PATIENTS BY STUDYING THE CHARACTERISTICS OF CEREBRAL HEMODYNAMICS AND CEREBRAL PERFUSION STATUS].

Likars'ka sprava Pub Date : 2015-07-01
N K Sviridova, V V Yavorsky
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Abstract

Intrigue progression of hypertensive encephalopathy (HE) in older patients is that the development of cognitive impairment and high blood pressure underestimated, aslo exist without clinical manifestations. In recent decades convincing proved that the basis for the development of various diseases is cerebral dysfunction systems regulating brain blood flow, including--autoregulation system, which largely affects the blood supply to the brain. This explains the fact that patients with chronic brain ischemia cerebral hemodynamic status largely depends on the condition and stability of the regulatory mechanisms of systemic and cerebral hemodynamics, particularly of systemic blood pressure, regional cerebral blood supply, normalization which, in the early stages of development disorders, prevents of serious complications. In this paper the theoretical generalization and new solution of scientific and practical problems of hypertension influence on the formation of chronic cerebral ischemia in elderly patients on a background of hypertension--specified risk factors and especially the formation of a comprehensive study on the basis of clinical and neurological data, tool sand methods for neuroimaging research developed and improved methods of diagnosis. Found that in elderly patients with HE and HBP observed significant (P < 0.05) increase in the thickness of the intima-media complex was significantly higher (dextra--1.12 ± 0.03 and sinistra--1.11 ± 0.03), than middle-aged patients with hypertension at HE, which constitutes a violation of the elastic properties of the vascular wall. Established correlation data radionuclide study ultrasonic duplex scanning of vessels of the head and neck. A negative correlation of intima-media and severity of lesions according to hypoperfusion of computer tomography single photon emission (r = -0.49; P < 0.05); confirming the progression of HE in elderly patients needs improvement and treatment.

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[通过研究脑血流动力学特征和脑灌注状态对老年高血压脑病脑血管疾病的诊断和治疗效果]。
高血压脑病(HE)在老年患者中的发展被低估为认知功能障碍和高血压,也存在无临床表现的情况。近几十年来令人信服地证明,各种疾病发展的基础是调节脑血流量的脑功能障碍系统,包括自动调节系统,它在很大程度上影响大脑的血液供应。这就解释了慢性脑缺血患者的脑血流动力学状态在很大程度上取决于全身和脑血流动力学调节机制的状况和稳定性,特别是全身血压、局部脑血供的正常化,在发育障碍的早期阶段可以防止严重并发症的发生。本文对高血压对老年患者慢性脑缺血形成的影响的科学和实际问题进行理论概括和新解决,以高血压为背景——明确危险因素的形成,特别是在临床和神经学资料的基础上,对神经影像学研究的工具和方法进行了综合研究,发展和改进了诊断方法。发现老年HE和HBP患者的内膜-中膜复合层厚度的增加(P < 0.05)明显高于中年HE高血压患者(dextra- 1.12±0.03和sininistra -1.11±0.03),这违反了血管壁的弹性特性。建立了头颈部血管超声双扫描的相关数据放射性核素研究。计算机断层单光子发射低灌注显示内膜-中膜与病变严重程度呈负相关(r = -0.49;P < 0.05);证实老年患者HE的进展需要改善和治疗。
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