Adult Stem Cells and Diabetes Therapy.

Journal of stem cell research and transplantation Pub Date : 2015-01-01 Epub Date: 2015-12-31
Handenur Ilgun, Joseph William Kim, LuGuang Luo
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Abstract

The World Health Organization estimates that diabetes will be the fourth most prevalent disease by 2050. Developing a new therapy for diabetes is a challenge for researchers and clinicians in field. Many medications are being used for treatment of diabetes however with no conclusive and effective results therefore alternative therapies are required. Stem cell therapy is a promising tool for diabetes therapy, and it has involved embryonic stem cells, adult stem cells, and pluripotent stem cells. In this review, we focus on adult stem cells, especial human bone marrow stem cells (BM) for diabetes therapy, its history, and current development. We discuss prospects for future diabetes therapy such as induced pluripotent stem cells which have popularity in stem cell research area.

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成体干细胞与糖尿病治疗。
世界卫生组织估计,到2050年,糖尿病将成为第四大流行疾病。开发一种新的治疗糖尿病的方法对该领域的研究人员和临床医生来说是一个挑战。许多药物被用于治疗糖尿病,但没有决定性和有效的结果,因此需要替代疗法。干细胞治疗是一种很有前途的糖尿病治疗工具,它涉及胚胎干细胞、成体干细胞和多能干细胞。本文就成体干细胞,特别是人骨髓干细胞在糖尿病治疗中的应用及其历史和发展现状作一综述。讨论了近年来干细胞研究领域中备受关注的诱导多能干细胞等治疗糖尿病的前景。
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