Phyllodes Tumor in a Lactating Breast.

Q3 Medicine Clinical Medicine Insights- Pathology Pub Date : 2016-04-06 eCollection Date: 2016-01-01 DOI:10.4137/CPath.S38476
Sudha S Murthy, K V V N Raju, Haripreetha G Nair
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引用次数: 9

Abstract

Phyllodes tumor is attributed to a small fraction of primary tumors of the breast. Such tumors occur rarely in pregnancy and lactation. We report a case of a 25-year-old lactating mother presenting with a lump in the left breast. Core needle biopsy was opined as phyllodes tumor with lactational changes, and subsequent wide local excision confirmed the diagnosis of benign phyllodes tumor with lactational changes. The characteristic gross and microscopic findings of a well-circumscribed lesion with leaf-like fibroepithelial growth pattern and typical nonuniform or diffuse stromal proliferation with periductal accentuation even in the absence of mitotic figures can help clinch the diagnosis. Benign phyllodes is known for its recurrence and requires wide excision and close follow-up. It is vital to identify these lesions even on limited biopsies as therapeutic options differ. This case is presented for its rarity and the diagnostic challenge it poses in limited biopsy.

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哺乳期乳腺叶状瘤。
叶状瘤被认为是乳腺原发肿瘤的一小部分。这种肿瘤很少发生在妊娠期和哺乳期。我们报告一个25岁的哺乳期母亲在左乳房出现肿块的病例。核心穿刺活检认为是乳腺变化的叶状瘤,随后广泛局部切除证实为乳腺变化的良性叶状瘤。典型的大体和显微镜检查结果显示,病灶边界清晰,叶状纤维上皮生长模式,典型的不均匀或弥漫性间质增生伴导管周围强化,即使没有有丝分裂象,也有助于确定诊断。良性叶状瘤以其复发而闻名,需要广泛切除和密切随访。即使在有限的活组织检查中识别这些病变也是至关重要的,因为治疗方案不同。本病例因其罕见性和在有限活检中提出的诊断挑战而被提出。
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