Maternal Risk Factors and Perinatal Characteristics for Hirschsprung Disease.

IF 6.4 2区医学 Q1 PEDIATRICS Pediatrics Pub Date : 2016-07-01 Epub Date: 2016-06-15 DOI:10.1542/peds.2015-4608

Anna Löf Granström, Anna Svenningsson, Eva Hagel, Jenny Oddsberg, Agneta Nordenskjöld, Tomas Wester

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引用次数: 36

Abstract

Background and objectives: Hirschsprung disease (HSCR) is a congenital defect of the enteric nervous system characterized by a lack of ganglion cells in the distal hindgut. The aim of this study was to assess the birth prevalence, perinatal characteristics, and maternal risk factors in HSCR patients in Sweden.

Methods: This was a nationwide, population-based, case-control study of all children born in Sweden between 1982 and 2012 and registered in the Swedish Medical Birth Register. Cases were identified in the Swedish National Patient Register and data on potential maternal risk factors and patient characteristics were collected from the Swedish National Patient Register and the Swedish Medical Birth Register. Five age- and sex-matched controls were randomly selected for each case. The association between studied risk factors and HSCR was analyzed using conditional logistic regression to calculate the odds ratio (OR) and 95% confidence interval (CI).

Results: The study population comprised 600 HSCR cases and 3000 controls with a male-to-female ratio of 3.7:1. The birth prevalence of HSCR was 1.91/10 000. Maternal obesity was associated with an increased risk for the child to have HSCR (OR 1.74; CI 1.25-2.44). Children with HSCR were born at an earlier gestational age (OR 1.60; CI 1.18-2.17) than control children. Associated malformations were identified in 34.5% of the cases.

Conclusions: This study showed that the Swedish birth prevalence of HSCR was 1.91/10 000. Children with HSCR disease were born at a lower gestational age than controls. Maternal obesity may increase the risk for the child to have HSCR.

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先天性巨结肠疾病的母体危险因素和围产期特征。

背景和目的:巨结肠病(HSCR)是一种先天性肠神经系统缺陷，其特征是后肠远端缺乏神经节细胞。本研究的目的是评估瑞典HSCR患者的出生患病率、围产期特征和产妇危险因素。方法:这是一项全国性的、以人群为基础的病例对照研究，研究对象是1982年至2012年间在瑞典出生并在瑞典医学出生登记处登记的所有儿童。在瑞典国家患者登记册中确定了病例，并从瑞典国家患者登记册和瑞典医疗出生登记册中收集了有关潜在产妇风险因素和患者特征的数据。每个病例随机选择5个年龄和性别匹配的对照组。采用条件logistic回归分析所研究的危险因素与HSCR之间的关系，计算优势比(OR)和95%置信区间(CI)。结果:研究人群包括600例HSCR病例和3000例对照，男女比例为3.7:1。出生时HSCR患病率为1.91/ 10000。母亲肥胖与孩子患HSCR的风险增加相关(OR 1.74;可信区间1.25 - -2.44)。患有HSCR的儿童出生在较早的胎龄(OR 1.60;CI 1.18-2.17)高于对照组。合并畸形占34.5%。结论:本研究显示瑞典出生HSCR患病率为1.91/ 10000。患有HSCR疾病的儿童出生时的胎龄低于对照组。母亲肥胖可能会增加孩子患HSCR的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatrics 医学-小儿科

CiteScore

12.80

自引率

5.00%

发文量

791

审稿时长

2-3 weeks

期刊介绍： The Pediatrics® journal is the official flagship journal of the American Academy of Pediatrics (AAP). It is widely cited in the field of pediatric medicine and is recognized as the leading journal in the field. The journal publishes original research and evidence-based articles, which provide authoritative information to help readers stay up-to-date with the latest developments in pediatric medicine. The content is peer-reviewed and undergoes rigorous evaluation to ensure its quality and reliability. Pediatrics also serves as a valuable resource for conducting new research studies and supporting education and training activities in the field of pediatrics. It aims to enhance the quality of pediatric outpatient and inpatient care by disseminating valuable knowledge and insights. As of 2023, Pediatrics has an impressive Journal Impact Factor (IF) Score of 8.0. The IF is a measure of a journal's influence and importance in the scientific community, with higher scores indicating a greater impact. This score reflects the significance and reach of the research published in Pediatrics, further establishing its prominence in the field of pediatric medicine.

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