Progress toward pharmacotherapies for cannabis-use disorder: an evidence-based review.

IF 5.1 Q1 SUBSTANCE ABUSE Substance Abuse and Rehabilitation Pub Date : 2016-05-03 eCollection Date: 2016-01-01 DOI:10.2147/SAR.S89857
Jan Copeland, Izabella Pokorski
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引用次数: 34

Abstract

Cannabis is the most widely used and variably regulated drug in the world, with increasing trends of use being reported in the US, Australia, Asia, and Africa. Evidence has shown a decrease in the age of commencement of cannabis use in some developed countries and a prolongation of risk of initiation to cannabis use beyond adolescence among more recent users. Cannabis use is associated with numerous health risks and long-term morbidity, as well as risk of developing cannabis-use disorders. Cannabis users infrequently seek professional treatment, and normally do so after a decade of use. Cannabis-use disorders are currently treated using a selection of psychosocial interventions. Severity of withdrawal is a factor that increases the risk of relapse, and is the target of pharmacotherapy studies. Currently, there is no approved pharmacotherapy for cannabis-use disorders. A number of approaches have been examined, and trials are continuing to find a safe and effective medication with little abuse liability.

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大麻使用障碍药物治疗的进展:基于证据的回顾。
大麻是世界上使用最广泛、管制最多变的药物,据报道,在美国、澳大利亚、亚洲和非洲,大麻的使用趋势日益增加。有证据表明,在一些发达国家,开始使用大麻的年龄有所下降,在最近的使用者中,青少年以后开始使用大麻的风险有所延长。大麻使用与许多健康风险和长期发病率以及产生大麻使用障碍的风险有关。吸食大麻的人很少寻求专业治疗,通常是在吸食十年之后。大麻使用障碍目前使用一系列心理社会干预措施进行治疗。戒断的严重程度是增加复发风险的一个因素,也是药物治疗研究的目标。目前,还没有批准的药物治疗大麻使用障碍。已经研究了许多方法,并且正在继续进行试验,以找到一种安全有效的药物,几乎没有滥用的危险。
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发文量
9
审稿时长
16 weeks
期刊最新文献
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