[THE ROLE OF (p)ppGpp MOLECULES IN FORMATION OF "STRICT RESPONSE" IN BACTERIA AND BIOSYNTHESIS OF ANTIBIOTICS AND MORPHOLOGICAL DIFFERENTIATION IN ACTINOMYCETES].

TSitologiia i genetika Pub Date : 2016-03-01
D Klymyshin, O Stephanyshyn, V Fedorenko
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Abstract

Strict response is a pleiotropic physiological response of cells caused by lack of aminoacetylated tRNAs. Experimentally, this response occurs due to the lack of amino acids in the environment and the limitation of tRNA aminoacylation even in the presence of the corresponding amino acids in the cell. Many features of this response indicate its dependence on the accumulation of ppGpp molecules. There is a correlation between the growth rate of actinomycetes and biosynthesis of their secondary metabolites. Introduction of additional relA gene copies of ppGpp synthetase can affect the production of antibiotics in streptomycetes. The article presents the authors' own experimental data, dedicated to the influence of heterologous relA gene expression in Streptomyces nogalater cells.

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ppGpp分子在细菌“严格反应”的形成、抗生素的生物合成和放线菌的形态分化中的作用。
严格反应是由于缺乏氨基乙酰化trna而引起的细胞的多效性生理反应。在实验中,这种反应的发生是由于环境中缺乏氨基酸以及即使在细胞中存在相应氨基酸的情况下tRNA氨基酰化的限制。这种反应的许多特征表明它依赖于ppGpp分子的积累。放线菌的生长速度与其次生代谢产物的生物合成有一定的相关性。引入ppGpp合成酶的额外relA基因拷贝可以影响链菌中抗生素的产生。本文介绍了作者自己的实验数据,致力于研究外源relA基因在nogalater链霉菌细胞中的表达。
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