Occurrence of Potential Bacterial Pathogens and Their Antimicrobial Susceptibility Patterns Isolated from Herbal Medicinal Products Sold in Different Markets of Gondar Town, Northwest Ethiopia.

International Journal of Bacteriology Pub Date : 2016-01-01 Epub Date: 2016-05-19 DOI:10.1155/2016/1959418
Abdela Yesuf, Yitayih Wondimeneh, Teklay Gebrecherkos, Feleke Moges
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引用次数: 12

Abstract

Background. The World Health Organization estimates that about 80% of the world's population uses herbal medicine to treat various illnesses as means of primary healthcare. However, during preparation, herbal plants may be exposed to contamination by potential pathogens, and this may lead to infections. The aim of this study was to determine bacterial contamination of herbal medicinal products and to assess the antibiotic susceptibility pattern of the isolated bacteria. Methods. A cross-sectional study was conducted from January 1 to May 25, 2013, at Gondar Town. A total of 55 samples used as oral, local, and intranasal routes of administration were collected from the herbalists. Results. In the present study the total aerobic bacterial count ranges from zero to 2.41 × 10(9) CFU/g with mean count of 1.99 × 10(8) CFU/g or mL while the total coliform count showed an average of 1.05 × 10(8) CFU/g or mL with a range of zero to 2.1 × 10(9) CFU/g. The most common bacteria isolated were Bacillus spp. followed by Enterobacter spp., Shigella dysenteriae, and Salmonella spp. Multiple drug resistance was not uncommon and it was found that 125 (83.4%) of the isolates were resistant to two or more antibiotics. Conclusion. Herbal medicinal preparations were highly contaminated with pathogenic microorganisms with high microbial load. Most of the isolates have multiple drug resistance. Using those contaminated herbal medicines may lead to infection of other health related risks. Therefore, this warrants urgent training of herbalists and management scale-up for quality and safety of medicinal plants.

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埃塞俄比亚西北部贡达尔镇不同市场销售的中药材中潜在致病菌的发生及药敏型分析
背景。世界卫生组织估计,世界上大约80%的人口使用草药作为初级卫生保健手段来治疗各种疾病。然而,在制备过程中,草药植物可能受到潜在病原体的污染,这可能导致感染。本研究的目的是确定中草药产品的细菌污染,并评估分离细菌的抗生素敏感性模式。方法。一项横断面研究于2013年1月1日至5月25日在Gondar镇进行。从中医师处共收集了55份用于口服、局部和鼻内给药途径的样本。结果。本研究中需氧细菌总数为0 ~ 2.41 × 10(9) CFU/g,平均为1.99 × 10(8) CFU/g或mL;大肠菌群总数为1.05 × 10(8) CFU/g或mL,平均为0 ~ 2.1 × 10(9) CFU/g。最常见的细菌是芽孢杆菌,其次是肠杆菌、痢疾志贺氏菌和沙门氏菌,多重耐药现象并不少见,其中125株(83.4%)对2种及2种以上抗生素耐药。结论。中草药制剂被病原微生物污染严重,微生物负荷较高。大多数分离株具有多重耐药。使用这些受污染的草药可能导致感染其他与健康相关的风险。因此,这需要对草药医师进行紧急培训,并扩大药用植物质量和安全管理。
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