Low DLCO in idiopathic pulmonary arterial hypertension - clinical correlates and prognostic significance.

Pneumonologia i alergologia polska Pub Date : 2016-01-01 DOI:10.5603/PiAP.2016.0006

Monika Szturmowicz, Aneta Kacprzak, Monika Franczuk, Barbara Burakowska, Marcin Kurzyna, Anna Fijałkowska, Agnieszka Skoczylas, Stefan Wesołowski, Jan Kuś, Adam Torbicki

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引用次数: 7

Abstract

Introduction: Decreased diffusing capacity of the lung for carbon monoxide (DLCO) is observed in some idiopathic pulmonary arterial hypertension (IPAH) patients, but its clinical significance is uncertain. We aimed to assess clinical correlates and prognostic significance of low DLCO in IPAH patients.

Material and methods: In the group of 65 IPAH patients the cut off value for low DLCO was set up based on histogram as < 55% of predicted value. Demographic data, exercise capacity, lung function tests, hemodynamic parameters and survival of the patients were compared depending on DLCO value.

Results: Low DLCO was found in 18% of the patients, and it was associated with male sex, older age, worse functional status and exercise capacity, and higher prevalence of coronary artery disease. Low DLCO carried a 4-fold increase of death risk in 5-year perspective.

Conclusions: Low DLCO was a marker of worse functional capacity and increased risk of death in studied IPAH patients.

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特发性肺动脉高压低DLCO的临床相关性及预后意义。

引言:在一些特发性肺动脉高压(IPAH)患者中可观察到肺对一氧化碳(DLCO)弥散能力降低，但其临床意义尚不明确。我们的目的是评估IPAH患者低DLCO的临床相关性和预后意义。材料与方法:在65例IPAH患者中，根据直方图设定低DLCO的临界值<预测值的55%。根据DLCO值比较患者的人口统计学资料、运动能力、肺功能测试、血流动力学参数和生存期。结果:18%的患者DLCO较低，与男性、年龄较大、功能状态和运动能力较差、冠状动脉疾病患病率较高有关。低DLCO患者5年死亡风险增加4倍。结论:低DLCO是IPAH患者功能能力差和死亡风险增加的标志。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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