[CHANGES IN MAC ANTIBODY LEVELS BEFORE AND AFTER SURGERY AND AT THE TIME OF RELAPSE/RECURRENCE IN MAC LUNG DISEASE--Can MAC Antibodies Be an Indicator of Postoperative Relapse/Recurrence?].

Kekkaku : [Tuberculosis] Pub Date : 2016-02-01

Katsuo Yamada, Yuuta Kawasumi, Ayuko Yasuda, Yukio Seki, Takashi Adachi, Osamu Tarumi, Yuuta Hayashi, Taku Nakagawa, Noritaka Yamada, Kenji Ogawa

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Abstract

Background: Patients receiving surgical treatment for Mycobacterium avium complex (MAC), lung disease should be followed up with careful attention paid to relapse/recurrence, but there is some debate regarding the findings based on which relapse/recurrence should be diagnosed.

Purpose and methods: We hypothesized that we might be able to use anti-GPL core IgA antibodies (MAC antibodies), which have been attracting attention as a factor that may support diagnosis of MAC lung disease, to diagnose postoperative relapse/recurrence. Therefore, we compared the levels of these antibodies before and at the time of relapse/recurrence, and also compared antibody titers before and after surgery.

Result: MAC antibody titers were elevated by an average of about 50% at the time of relapse/recurrence compared to those before relapse/recurrence for 6 patients. In contrast, MAC antibody titers were about 30% lower after surgery compared to those before surgery for 37 patients.

Conclusion: It may be possible to use MAC antibodies as an indicator of postoperative relapse/recurrence for MAC lung disease.

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[MAC肺部疾病手术前后和复发/复发时MAC抗体水平的变化——MAC抗体能否作为术后复发/复发的指标?]。

背景:接受鸟分枝杆菌复合体(MAC)手术治疗的肺部疾病患者应密切关注复发/复发，但对于复发/复发的诊断结果存在一些争论。目的和方法:我们假设我们可以使用抗gpl核心IgA抗体(MAC抗体)来诊断术后复发/复发，这是一个备受关注的可能支持MAC肺部疾病诊断的因素。因此，我们比较了这些抗体在复发/复发前和复发时的水平，也比较了手术前后的抗体滴度。结果:6例患者复发/复发时MAC抗体滴度较复发/复发前平均升高约50%。相比之下，37例患者术后MAC抗体滴度比术前降低约30%。结论:MAC抗体有可能作为MAC肺部疾病术后复发的指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Kekkaku : [Tuberculosis]

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