Elbasvir/Grazoprevir: A Review of the Latest Agent in the Fight against Hepatitis C.

IF 1.5 Q3 GASTROENTEROLOGY & HEPATOLOGY International Journal of Hepatology Pub Date : 2016-01-01 Epub Date: 2016-06-15 DOI:10.1155/2016/3852126
Allison M Bell, Jamie L Wagner, Katie E Barber, Kayla R Stover
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引用次数: 33

Abstract

Hepatitis C virus (HCV) is estimated to affect up to 150 million people worldwide. Despite worldwide prevalence, treatment modalities prior to 2011 remained suboptimal, with low virologic response rates and intolerable side effect profiles. Fortunately, the landscape of treatment for chronic hepatitis C has rapidly evolved since the introduction of HCV NS3/4 protease inhibitors in 2011. Elbasvir, a NS5A inhibitor, combined with grazoprevir, a NS3/4A protease inhibitor, is the latest FDA-approved therapy for patients with genotype 1 or 4 chronic hepatitis C, with or without compensated cirrhosis. This review will focus on the current literature and clinical evidence supporting elbasvir/grazoprevir as first-line therapy in patients with genotypes 1 and 4 chronic hepatitis C.

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Elbasvir/Grazoprevir:抗丙型肝炎最新药物综述
据估计,全世界有1.5亿人感染丙型肝炎病毒(HCV)。尽管在世界范围内流行,但2011年之前的治疗方式仍然不理想,病毒学反应率低,副作用难以忍受。幸运的是,自2011年引入HCV NS3/4蛋白酶抑制剂以来,慢性丙型肝炎的治疗前景迅速发展。Elbasvir(一种NS5A抑制剂)联合grazoprevir(一种NS3/4A蛋白酶抑制剂)是fda批准的最新治疗1型或4型慢性丙型肝炎伴或不伴代偿性肝硬化患者的药物。本综述将重点关注目前支持elbasvir/grazoprevir作为1型和4型慢性丙型肝炎患者一线治疗的文献和临床证据。
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来源期刊
International Journal of Hepatology
International Journal of Hepatology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
3.80
自引率
0.00%
发文量
11
审稿时长
15 weeks
期刊介绍: International Journal of Hepatology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the medical, surgical, pathological, biochemical, and physiological aspects of hepatology, as well as the management of disorders affecting the liver, gallbladder, biliary tree, and pancreas.
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