Chronic Epstein Barr virus infection leading to classical Hodgkin lymphoma.

Q2 Medicine BMC Hematology Pub Date : 2016-07-19 eCollection Date: 2016-01-01 DOI:10.1186/s12878-016-0059-3

Nawid M Sarwari, Joseph D Khoury, Cristhiam M Rojas Hernandez

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引用次数: 19

Abstract

Background: Chronic Epstein Barr virus (EBV) infection in an immunocompetent host has been described however it is not a common entity. It has been linked to many lymphoproliferative disorders and achieves such via many molecular mechanisms, some of which are poorly understood. In addition to infectious mononucleosis, the EBV is linked to various other hematological pathologies and autoimmune disorders.

Case presentation: We describe the case of an elderly immunocompetent female who presented with non-specific symptomatology, lymphadenopathy, cytopenias, elevated autoantibody titers and a crescent EBV viral load that were suggestive of a multisystemic inflammatory disease related to EBV. Extensive work up including multiple bone marrow biopsy and lymphoid tissue procedures ultimately led to the diagnosis of Hodgkin lymphoma.

Conclusion: EBV-related lymphomagenesis is complex and through the utilization of its nuclear antigens and latent membrane proteins the virus is able to shape the microenvironment to promote the various pathologies seen. Moreover, the diagnosis of EBV-associated lymphoproliferative disorders might be challenging when they present in immunocompetent individuals. Our case also represents an emphatic reminder for clinicians that spontaneous regression of lymphadenopathy is not exclusive of low-grade lymphoid malignancies.

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慢性eb病毒感染导致经典霍奇金淋巴瘤。

背景:慢性eb病毒(EBV)感染在免疫能力强的宿主中已被描述，但它不是一个常见的实体。它与许多淋巴增生性疾病有关，并通过许多分子机制实现，其中一些机制尚不清楚。除了传染性单核细胞增多症外，EBV还与其他各种血液学病理和自身免疫性疾病有关。病例介绍:我们描述了一位老年免疫功能正常的女性，她表现出非特异性症状，淋巴结病变，细胞减少，自身抗体滴度升高和新月型EBV病毒载量，提示与EBV相关的多系统炎症性疾病。包括多次骨髓活检和淋巴组织检查在内的广泛工作最终导致了霍奇金淋巴瘤的诊断。结论:ebv相关的淋巴瘤发生是复杂的，通过利用其核抗原和潜伏膜蛋白，该病毒能够塑造微环境，促进所见的各种病理。此外，当eb病毒相关的淋巴增生性疾病出现在免疫功能正常的个体中时，诊断可能具有挑战性。我们的病例也强烈提醒临床医生，淋巴结病的自发消退并不仅限于低级别淋巴样恶性肿瘤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Hematology Medicine-Hematology

CiteScore

4.10

自引率

0.00%

发文量

期刊介绍： BMC Hematology is an open access, peer-reviewed journal that considers articles on basic, experimental and clinical research related to hematology. The journal welcomes submissions on non-malignant and malignant hematological diseases, hemostasis and thrombosis, hematopoiesis, stem cells and transplantation.