Synthesis and screening of peptide libraries with free C-termini.
Pub Date : 2014-01-01
Yen-Chih Wang, Mark D Distefano
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引用次数: 0
Abstract
Peptide libraries are useful tools to investigate the relationship between structure and function of proteins. The creation of peptide libraries with free C-termini presents unique synthetic challenges. In this review, methods for creating peptide libraries using either solid-phase peptide synthesis or phage display are described. Methods for screening such libraries and their application in studying several important biological problems are also reported.
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