The Somatotrope Growth Hormone-Releasing Hormone/Growth Hormone/Insulin-Like Growth Factor-1 Axis in Immunoregulation and Immunosenescence.

2区医学 Q2 Medicine Frontiers of Hormone Research Pub Date : 2017-01-01 Epub Date: 2017-02-28 DOI:10.1159/000452913

Gwennaëlle Bodart, Khalil Farhat, Chantal Charlet-Renard, Roberto Salvatori, Vincent Geenen, Henri Martens

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引用次数: 20

Abstract

Most scientific reports debate the thymotropic and immuno-stimulating properties of the somatotrope growth hormone-releasing hormone (GHRH)/growth hormone (GH)/insulin-like growth factor (IGF)-1 axis, but there is still some disagreement about the physiological role of this axis in basal conditions. Moreover, some authors have hypothesized that the physiological role of the somatotrope axis only appears in stressful conditions (such as sepsis or infective and inflammatory diseases). This chapter will provide an extended overview of the expression of the components (signals and receptors) of the somatotrope axis and their properties on cells of the innate and adaptive immune system. It will also summarize some clinical studies suggesting a benefit for a short-term GH treatment in acute immunodeficiencies, and the importance of GH supplementation in adult GH deficiency. A new transgenic mouse model, the hypothalamic GHRH-deficient (Ghrh-/-) mouse, which exhibits a severe deficiency of the somatotrope axis, will be presented since it will be of great help in further deciphering the regulation by the GHRH/GH/IGF-1 axis on both immune development and function. Finally, we will discuss the implication of aging-related somatopause in relation to the general context of Immunosenescence.

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生长激素-释放激素/生长激素/胰岛素样生长因子-1轴在免疫调节和免疫衰老中的作用。

大多数科学报告对促生长激素释放激素(GHRH)/生长激素(GH)/胰岛素样生长因子(IGF)-1轴的促胸腺和免疫刺激特性存在争议，但对该轴在基础条件下的生理作用仍存在一些分歧。此外，一些作者假设，促生长轴的生理作用只出现在应激条件下(如败血症或感染性和炎症性疾病)。本章将提供一个扩展概述的成分(信号和受体)的表达和它们的性质在先天和适应性免疫系统的细胞。它还将总结一些临床研究表明短期生长激素治疗急性免疫缺陷的益处，以及在成人生长激素缺乏症中补充生长激素的重要性。我们将提出一种新的转基因小鼠模型——下丘脑Ghrh-缺陷小鼠(Ghrh-/-)，这种小鼠表现出严重的生长斜变性轴缺陷，因为它将有助于进一步解读Ghrh /GH/IGF-1轴对免疫发育和功能的调节。最后，我们将讨论与免疫衰老有关的衰老相关的躯体停育的含义。

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Frontiers of Hormone Research 医学-内分泌学与代谢

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期刊介绍： A series of integrated overviews on cutting-edge topics New sophisticated technologies and methodological approaches in diagnostics and therapeutics have led to significant improvements in identifying and characterizing an increasing number of medical conditions, which is particularly true for all aspects of endocrine and metabolic dysfunctions. Novel insights in endocrine physiology and pathophysiology allow for new perspectives in clinical management and thus lead to the development of molecular, personalized treatments. In view of this, the active interplay between basic scientists and clinicians has become fundamental, both to provide patients with the most appropriate care and to advance future research.